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• W2759206297 startingPage "20170278" @default.
• W2759206297 abstract "Objective: To investigate the radiation-induced abscopal effect in terms of oxidative stress, apoptosis and DNA damage in the spleen cells following cranial X-rays irradiation of rats. Methods: Rats were cranially irradiated using 2 Gy X-rays. Another group was whole-body irradiated with 2 Gy X-rays and a third group was exposed to scattered radiation (measured to be 3 mGy). 24 hours following irradiation, sections from the spleen of the rats were dissected as well as plasma samples. The samples were examined for the desired endpoints. Results: The cranially irradiated animals showed a significant increase in the levels of glutathione, superoxide dismutase and catalase with no significant change in the lipid peroxidation product in the spleen cells with a significant increase in the C-reactive protein level the plasma. Apoptotic cell death in the spleen cells was demonstrated as indicated by the decrease of Bcl-2; the increase of p53, Bax, caspase-3 and caspase-8 and induction of DNA damage in the spleen in both of the cranially irradiated rats and whole body exposed rats. The exposure to 3 mGy scattered radiation increased the plasma level of C-RP and also induced apoptosis in the spleen cells. Conclusion: Cranial irradiation-induced abscopal effect in distant spleen cells. Very low doses of radiation can induce apoptosis in the spleen cells. Advances in knowledge: This paper provides an evidence on the incidence of radiation abscopal effect. Also, the results shed light of the effect very low doses of radiation as low as 3 mGy." @default.
• W2759206297 created "2017-10-06" @default.
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• W2759206297 date "2017-12-01" @default.
• W2759206297 modified "2023-10-18" @default.
• W2759206297 title "Radiation induced bystander effects in the spleen of cranially-irradiated rats" @default.
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• W2759206297 doi "https://doi.org/10.1259/bjr.20170278" @default.
• W2759206297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6047657" @default.
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