Matches in SemOpenAlex for { <https://semopenalex.org/work/W2759216958> ?p ?o ?g. }
- W2759216958 endingPage "8276" @default.
- W2759216958 startingPage "8265" @default.
- W2759216958 abstract "The imbalance between effector CD4+ T helper 17 (Th17) and regulatory CD4+ T cells (Treg) cells and their associated cytokines, have been associated with the pathogenesis of inflammatory bowel disease (IBD). Total glycosides of paeony (TGP) is an alternative immunomodulatory agent that is widely used for the treatment of autoimmune diseases. The present study aimed to evaluate the modulatory effect of TGP in a rat model of colitis induced by 2,4,6‑trinitrobenzene sulfonic acid (TNBS). TGP was administered intragastrically 24 h after the TNBS intrarectal instillation for 7 days. TGP treatment ameliorated the clinical status and reversed the histopathologic severity of acute TNBS colitis. Furthermore, TGP inhibited the levels of Th17‑associated cytokines interleukin (IL)‑17, IL‑6, tumor necrosis factor‑α, whereas the expression levels of Treg‑associated cytokines IL‑10, transforming growth factor‑β in the plasma, colon, spleen and mesenteric lymph nodes (MLN). Additionally, TGP reduced the percentage of Th17 cells; however, the proportion of Treg cells in the spleen and MLN was increased. The present study also observed a suppression of Th17‑associated transcription factor, termed retinoid‑related orphan receptor‑γt (ROR‑γt). However, expression of the Treg‑associated transcription factor forkhead boxp3 was increased in the TGP treatment group. Therefore, the present findings suggest that TGP has a regulatory role in modulating the balance of Th17 and Treg cells to ameliorate the TNBS‑induced colitis and support the strategy of using TGP to treat IBD." @default.
- W2759216958 created "2017-10-06" @default.
- W2759216958 creator A5008283130 @default.
- W2759216958 creator A5014592972 @default.
- W2759216958 creator A5052948969 @default.
- W2759216958 creator A5055223854 @default.
- W2759216958 creator A5055992431 @default.
- W2759216958 creator A5083064491 @default.
- W2759216958 date "2017-09-25" @default.
- W2759216958 modified "2023-09-27" @default.
- W2759216958 title "Total glucosides of paeony ameliorates TNBS-induced colitis by modulating differentiation of Th17/Treg cells and the secretion of cytokines" @default.
- W2759216958 cites W1491988578 @default.
- W2759216958 cites W1545517148 @default.
- W2759216958 cites W1548313389 @default.
- W2759216958 cites W1980018183 @default.
- W2759216958 cites W1981815467 @default.
- W2759216958 cites W1988964423 @default.
- W2759216958 cites W1993753740 @default.
- W2759216958 cites W1998510547 @default.
- W2759216958 cites W2002726823 @default.
- W2759216958 cites W2005553679 @default.
- W2759216958 cites W2008924149 @default.
- W2759216958 cites W2011319298 @default.
- W2759216958 cites W2014750930 @default.
- W2759216958 cites W2016742425 @default.
- W2759216958 cites W2017530018 @default.
- W2759216958 cites W2018477911 @default.
- W2759216958 cites W2024368831 @default.
- W2759216958 cites W2025813544 @default.
- W2759216958 cites W2034979817 @default.
- W2759216958 cites W2045528738 @default.
- W2759216958 cites W2046946103 @default.
- W2759216958 cites W2048045582 @default.
- W2759216958 cites W2063731747 @default.
- W2759216958 cites W2078621117 @default.
- W2759216958 cites W2080965165 @default.
- W2759216958 cites W2086968599 @default.
- W2759216958 cites W2088728349 @default.
- W2759216958 cites W2095164057 @default.
- W2759216958 cites W2097811455 @default.
- W2759216958 cites W2099376515 @default.
- W2759216958 cites W2100852829 @default.
- W2759216958 cites W2107277218 @default.
- W2759216958 cites W2110491264 @default.
- W2759216958 cites W2112866067 @default.
- W2759216958 cites W2123249923 @default.
- W2759216958 cites W2126874760 @default.
- W2759216958 cites W2129805475 @default.
- W2759216958 cites W2130865756 @default.
- W2759216958 cites W2141265087 @default.
- W2759216958 cites W2142017607 @default.
- W2759216958 cites W2155779547 @default.
- W2759216958 cites W2157090771 @default.
- W2759216958 cites W2167433319 @default.
- W2759216958 cites W2171463669 @default.
- W2759216958 cites W2212226399 @default.
- W2759216958 cites W2776663677 @default.
- W2759216958 cites W4211241312 @default.
- W2759216958 doi "https://doi.org/10.3892/mmr.2017.7598" @default.
- W2759216958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28944916" @default.
- W2759216958 hasPublicationYear "2017" @default.
- W2759216958 type Work @default.
- W2759216958 sameAs 2759216958 @default.
- W2759216958 citedByCount "14" @default.
- W2759216958 countsByYear W27592169582018 @default.
- W2759216958 countsByYear W27592169582019 @default.
- W2759216958 countsByYear W27592169582020 @default.
- W2759216958 countsByYear W27592169582021 @default.
- W2759216958 countsByYear W27592169582022 @default.
- W2759216958 countsByYear W27592169582023 @default.
- W2759216958 crossrefType "journal-article" @default.
- W2759216958 hasAuthorship W2759216958A5008283130 @default.
- W2759216958 hasAuthorship W2759216958A5014592972 @default.
- W2759216958 hasAuthorship W2759216958A5052948969 @default.
- W2759216958 hasAuthorship W2759216958A5055223854 @default.
- W2759216958 hasAuthorship W2759216958A5055992431 @default.
- W2759216958 hasAuthorship W2759216958A5083064491 @default.
- W2759216958 hasBestOaLocation W27592169581 @default.
- W2759216958 hasConcept C126322002 @default.
- W2759216958 hasConcept C164027704 @default.
- W2759216958 hasConcept C17991360 @default.
- W2759216958 hasConcept C203014093 @default.
- W2759216958 hasConcept C2775862500 @default.
- W2759216958 hasConcept C2776914184 @default.
- W2759216958 hasConcept C2778260677 @default.
- W2759216958 hasConcept C2779134260 @default.
- W2759216958 hasConcept C2779237934 @default.
- W2759216958 hasConcept C2779727006 @default.
- W2759216958 hasConcept C2780931953 @default.
- W2759216958 hasConcept C2780942790 @default.
- W2759216958 hasConcept C47348012 @default.
- W2759216958 hasConcept C502942594 @default.
- W2759216958 hasConcept C71924100 @default.
- W2759216958 hasConcept C74737994 @default.
- W2759216958 hasConcept C8891405 @default.
- W2759216958 hasConceptScore W2759216958C126322002 @default.
- W2759216958 hasConceptScore W2759216958C164027704 @default.
- W2759216958 hasConceptScore W2759216958C17991360 @default.