Matches in SemOpenAlex for { <https://semopenalex.org/work/W2759372778> ?p ?o ?g. }
- W2759372778 endingPage "1507" @default.
- W2759372778 startingPage "1497" @default.
- W2759372778 abstract "Cervical cancer is one of the most common malignant tumors in women all over the world. However, the exact etiology of cervical cancer remains unclear. The receptor for activated protein kinase C (RACK1) is reported to be involved in tumorigenesis and tumor progression. Besides, the prognostic value of RACK1 in several kinds of tumors has been identified. However, there are limited studies on the functional role of RACK1 in cervical cancer. In this study, we tested the expression level of RACK1 by immunohistochemistry and western blot technologies and find that it is upregulated in cervical cancer. Colony formation and CCK8 assays indicate that RACK1 promotes cell proliferation in CaSki cervical cancer cells. While the silence of RACK1 decreases the cell proliferation in CCK8 analysis. β-galactosidase staining suggests that RACK1 decreases cell senescence in cervical cancer cells. Invasion and migration assay show that RACK1 promotes the invasion and migration of cervical cancer cells. Also, when RACK1 was silenced, it exerts the opposite result. Furthermore, the mRNA expression levels of MMP‑3, MMP‑9 and MMP‑10 were upregulated in RACK1‑overexpressed CaSki cells by qPCR analysis. RACK1 also induces S phase accumulation in cell cycle analysis and suppresses cell apoptosis in cervical cancer cells. Flow cytometry analysis of mitochondria functions suggests that RACK1 increases the mitochondrial membrane potential (Δψm) levels to prevent mitochondrial apoptosis in cervical cancer cells. To explore the possible mechanism of RACK1, we tested and found that RACK1 upregulates the expression of NF-κB, cyclin D1 and CDK4 and downregulates the expression of p53, p38, p21 and STAT1 in cervical cancer cells. These results suggest that RACK1 promotes cell growth and invasion and inhibits the senescence and apoptosis in cervical cancer cells probably by affecting the p53 pathway." @default.
- W2759372778 created "2017-10-06" @default.
- W2759372778 creator A5003324129 @default.
- W2759372778 creator A5004116656 @default.
- W2759372778 creator A5011130387 @default.
- W2759372778 creator A5013796517 @default.
- W2759372778 creator A5013953750 @default.
- W2759372778 creator A5024766789 @default.
- W2759372778 creator A5026122415 @default.
- W2759372778 creator A5039627537 @default.
- W2759372778 creator A5065237130 @default.
- W2759372778 creator A5074028169 @default.
- W2759372778 creator A5076563235 @default.
- W2759372778 creator A5088617130 @default.
- W2759372778 creator A5090350458 @default.
- W2759372778 date "2017-09-27" @default.
- W2759372778 modified "2023-10-17" @default.
- W2759372778 title "The receptor for activated protein kinase C promotes cell growth, invasion and migration in cervical cancer" @default.
- W2759372778 cites W1500453171 @default.
- W2759372778 cites W1848812244 @default.
- W2759372778 cites W1967934704 @default.
- W2759372778 cites W1972915445 @default.
- W2759372778 cites W1976886432 @default.
- W2759372778 cites W1983065127 @default.
- W2759372778 cites W1985850556 @default.
- W2759372778 cites W1990316655 @default.
- W2759372778 cites W1990743609 @default.
- W2759372778 cites W2000436863 @default.
- W2759372778 cites W2005296060 @default.
- W2759372778 cites W2008978535 @default.
- W2759372778 cites W2010743146 @default.
- W2759372778 cites W2015050458 @default.
- W2759372778 cites W2021505095 @default.
- W2759372778 cites W2026004604 @default.
- W2759372778 cites W2026408479 @default.
- W2759372778 cites W2040849517 @default.
- W2759372778 cites W2041280565 @default.
- W2759372778 cites W2042073539 @default.
- W2759372778 cites W2049275490 @default.
- W2759372778 cites W2052853635 @default.
- W2759372778 cites W2066447633 @default.
- W2759372778 cites W2066509081 @default.
- W2759372778 cites W2074740400 @default.
- W2759372778 cites W2075311654 @default.
- W2759372778 cites W2075679064 @default.
- W2759372778 cites W2082319264 @default.
- W2759372778 cites W2082743261 @default.
- W2759372778 cites W2086283096 @default.
- W2759372778 cites W2087875641 @default.
- W2759372778 cites W2091206873 @default.
- W2759372778 cites W2097136004 @default.
- W2759372778 cites W210599113 @default.
- W2759372778 cites W2106787323 @default.
- W2759372778 cites W2118165245 @default.
- W2759372778 cites W2120343162 @default.
- W2759372778 cites W2129029860 @default.
- W2759372778 cites W2138640452 @default.
- W2759372778 cites W2146428402 @default.
- W2759372778 cites W2159440113 @default.
- W2759372778 cites W2168008823 @default.
- W2759372778 cites W2278900005 @default.
- W2759372778 cites W2341101391 @default.
- W2759372778 cites W2344048868 @default.
- W2759372778 cites W2346443283 @default.
- W2759372778 cites W2386480566 @default.
- W2759372778 cites W2408912979 @default.
- W2759372778 cites W2475508157 @default.
- W2759372778 cites W2501305632 @default.
- W2759372778 cites W2605999118 @default.
- W2759372778 cites W2607270046 @default.
- W2759372778 cites W2742041829 @default.
- W2759372778 cites W2742157864 @default.
- W2759372778 doi "https://doi.org/10.3892/ijo.2017.4137" @default.
- W2759372778 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5642390" @default.
- W2759372778 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29048616" @default.
- W2759372778 hasPublicationYear "2017" @default.
- W2759372778 type Work @default.
- W2759372778 sameAs 2759372778 @default.
- W2759372778 citedByCount "16" @default.
- W2759372778 countsByYear W27593727782018 @default.
- W2759372778 countsByYear W27593727782019 @default.
- W2759372778 countsByYear W27593727782020 @default.
- W2759372778 countsByYear W27593727782021 @default.
- W2759372778 countsByYear W27593727782022 @default.
- W2759372778 countsByYear W27593727782023 @default.
- W2759372778 crossrefType "journal-article" @default.
- W2759372778 hasAuthorship W2759372778A5003324129 @default.
- W2759372778 hasAuthorship W2759372778A5004116656 @default.
- W2759372778 hasAuthorship W2759372778A5011130387 @default.
- W2759372778 hasAuthorship W2759372778A5013796517 @default.
- W2759372778 hasAuthorship W2759372778A5013953750 @default.
- W2759372778 hasAuthorship W2759372778A5024766789 @default.
- W2759372778 hasAuthorship W2759372778A5026122415 @default.
- W2759372778 hasAuthorship W2759372778A5039627537 @default.
- W2759372778 hasAuthorship W2759372778A5065237130 @default.
- W2759372778 hasAuthorship W2759372778A5074028169 @default.
- W2759372778 hasAuthorship W2759372778A5076563235 @default.
- W2759372778 hasAuthorship W2759372778A5088617130 @default.