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• W2759580840 abstract "2646 Aberrant promoter hypermethylation of several known or putative tumor suppressor genes occurs frequently during carcinogenesis and this epigenetic change has been considered as a potential molecular marker for cancer. It would be very important to identify new cancer specific epigenetic alterations in different stages of tumor type to elucidate its tumorigenesis and clinical management.
 We examined the changes in methylation patterns of several genes (ESR1, APC, CDH1, CTNNB1, GSTPI, THBS1, MGMT, TMS1 and TIMP3) by candidate gene approach during ductal breast cancer progression from atypical ductal hyperplasia to in situ and invasive carcinoma. Twenty age-matched normal and paired samples of synchronous pre invasive lesions (Atypical Ductal Hyperplasia and/or Ductal Carcinoma in situ) and invasive ductal breast carcinoma from 31 patients were studied. By establishing an empiric cutoff value, we calculated the frequency of methylation in tumors of different types of paired samples and controls and finally for validation of the frequency of methylation we tested additional isolated lesion 8 DCIS AND 16 IDC from 24 samples. Overall, 95 pathological samples and 20 normal breast tissues were analyzed by Quantitative Methylation Specific PCR (QMSP). APC, CDH1, and CTNNB1 promoter regions showed an increase in frequency of methylation and increased methylation levels in pathological samples when compared with normal breast tissues. The analysis of the syncronous paired breast lesions demonstrated an increase in methylation frequency and level for APC, CDH1, and CTNNB1 genes during progression. By establishing a cutoff value, we were able to distinguish among pre-invasive and invasive lesions. Synchronous methylation of APC, CDH1, and CTNNB1 was associated only with invasive lesions, whereas simultaneous methylation of APC and CDH1 or APC and CTNNB1 were more frequent in ductal carcinoma in situ and invasive carcinoma. Our data point to direct involvement of APC, CDH1, and CTNNB1 CpG island promoter methylation in the early stages of breast cancer progression, and suggest that these molecular alterations might be involved in the transition to an invasive phenotype." @default.
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• W2759580840 date "2008-05-01" @default.
• W2759580840 modified "2023-09-23" @default.
• W2759580840 title "Changes in CpG islands methylation patterns during ductal breast carcinoma progression." @default.
• W2759580840 hasPublicationYear "2008" @default.
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