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• W2759595737 abstract "This study demonstrates the utility of the newly developed self-assembly-induced gelation technique for the synthesis of porous collagen/hydroxyapatite (HA) composite microspheres with a nanofibrous structure. This new approach can produce microspheres of a uniform size using the droplets that form at the nozzle tip before gelation. These microspheres can have a highly nanofibrous structure due to the immersion of the droplets in a coagulation bath (water/acetone), in which the collagen aggregates in the solution can self-assemble into fibrils due to pH-dependent precipitation. Bioactive HA particles were incorporated into the collagen solutions, in order to enhance the bioactivity of the composite microspheres. The composite microspheres exhibited a well-defined spherical morphology and a uniform size for all levels of HA content (0 wt %, 10 wt %, 15 wt %, and 20 wt %). Collagen nanofibers—several tens of nanometers in size—were uniformly present throughout the microspheres and the HA particles were also well dispersed. The in vitro apatite-forming ability, assessed using the simulated body fluid (SBF) solution, increased significantly with the incorporation of HA into the composite microspheres." @default.
• W2759595737 created "2017-10-06" @default.
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• W2759595737 date "2017-09-21" @default.
• W2759595737 modified "2023-09-29" @default.
• W2759595737 title "Novel Self-Assembly-Induced Gelation for Nanofibrous Collagen/Hydroxyapatite Composite Microspheres" @default.
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• W2759595737 doi "https://doi.org/10.3390/ma10101110" @default.
• W2759595737 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5666916" @default.
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