FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2759595942> ?p ?o ?g. }

• W2759595942 abstract "ABSTRACT Animals integrate external cues with information about internal conditions such as metabolic state to execute the appropriate behavioral and developmental decisions. Information about food quality and quantity is assessed by the intestine and transmitted to modulate neuronal functions via mechanisms that are not fully understood. The conserved Target of Rapamycin complex 2 (TORC2) controls multiple processes in response to cellular stressors and growth factors. Here we show that TORC2 coordinates larval development and adult behaviors in response to environmental cues and feeding state in the bacterivorous nematode C. elegans . During development, pheromone, bacterial food, and temperature regulate expression of the daf-7 TGF-β and daf-28 insulin-like peptide in sensory neurons to promote a binary decision between reproductive growth and entry into the alternate dauer larval stage. We find that TORC2 acts in the intestine to regulate neuronal expression of both daf-7 and daf-28, which together reflect bacterial-diet dependent feeding status, thus providing a mechanism for integration of food signals with external cues in the regulation of neuroendocrine gene expression. In the adult, TORC2 similarly acts in the intestine to modulate food-regulated foraging behaviors via the PDFR-1 neuropeptide receptor. We also demonstrate that genetic variation affects food-dependent larval and adult phenotypes, and identify quantitative trait loci (QTL) associated with these traits.Together, these results suggest that TORC2 acts as a hub for communication of feeding state information from the gut to the brain, thereby contributing to modulation of neuronal function by internal state. AUTHOR SUMMARY Decision-making in all animals, including humans, involves weighing available information about the external environment as well as the animals’ internal conditions. Information about the environment is obtained via the sensory nervous system, whereas internal state can be assessed via cues such as levels of hormones or nutrients. How multiple external and internal inputs are processed in the nervous system to drive behavior or development is not fully understood. In this study, we examine how the nematode C. elegans integrates dietary information received by the gut with environmental signals to alter nervous system function. We have found that a signaling complex, called TORC2, acts in the gut to relay nutrition signals to alter hormonal signaling by the nervous system in C. elegans . Altered neuronal signaling in turn affects a food-dependent binary developmental decision in larvae, as well as food-dependent foraging behaviors in adults. Our results provide a mechanism by which animals prioritize specific signals such as feeding status to appropriately alter their development and/or behavior." @default.
• W2759595942 created "2017-10-06" @default.
• W2759595942 creator A5012857095 @default.
• W2759595942 creator A5029906460 @default.
• W2759595942 creator A5029961526 @default.
• W2759595942 creator A5058144096 @default.
• W2759595942 date "2017-09-21" @default.
• W2759595942 modified "2023-09-29" @default.
• W2759595942 title "Rictor/TORC2 mediates gut-to-brain signaling in the regulation of phenotypic plasticity in C. elegans" @default.
• W2759595942 cites W1554974851 @default.
• W2759595942 cites W1558528060 @default.
• W2759595942 cites W1561443084 @default.
• W2759595942 cites W1806984011 @default.
• W2759595942 cites W1820848997 @default.
• W2759595942 cites W1913729442 @default.
• W2759595942 cites W1966145280 @default.
• W2759595942 cites W1969645371 @default.
• W2759595942 cites W1971104905 @default.
• W2759595942 cites W1971703620 @default.
• W2759595942 cites W1974390921 @default.
• W2759595942 cites W1975751348 @default.
• W2759595942 cites W1976416661 @default.
• W2759595942 cites W1977533635 @default.
• W2759595942 cites W1979653032 @default.
• W2759595942 cites W1980216636 @default.
• W2759595942 cites W1986574990 @default.
• W2759595942 cites W2008616131 @default.
• W2759595942 cites W2009484058 @default.
• W2759595942 cites W2011364906 @default.
• W2759595942 cites W2014128649 @default.
• W2759595942 cites W2034605152 @default.
• W2759595942 cites W2034741138 @default.
• W2759595942 cites W2034742459 @default.
• W2759595942 cites W2037565038 @default.
• W2759595942 cites W2038120788 @default.
• W2759595942 cites W2044400161 @default.
• W2759595942 cites W2044747088 @default.
• W2759595942 cites W2047495081 @default.
• W2759595942 cites W2047528119 @default.
• W2759595942 cites W2049741320 @default.
• W2759595942 cites W2051648135 @default.
• W2759595942 cites W2060297895 @default.
• W2759595942 cites W2062392960 @default.
• W2759595942 cites W2063378473 @default.
• W2759595942 cites W2064144155 @default.
• W2759595942 cites W2064185036 @default.
• W2759595942 cites W2068465378 @default.
• W2759595942 cites W2069702337 @default.
• W2759595942 cites W2070217895 @default.
• W2759595942 cites W2078821200 @default.
• W2759595942 cites W2080029391 @default.
• W2759595942 cites W2080802801 @default.
• W2759595942 cites W2083294863 @default.
• W2759595942 cites W2088019468 @default.
• W2759595942 cites W2090527143 @default.
• W2759595942 cites W2091617571 @default.
• W2759595942 cites W2098328813 @default.
• W2759595942 cites W2099741025 @default.
• W2759595942 cites W2101400941 @default.
• W2759595942 cites W2103246958 @default.
• W2759595942 cites W2103846905 @default.
• W2759595942 cites W2105326400 @default.
• W2759595942 cites W2108024591 @default.
• W2759595942 cites W2109188407 @default.
• W2759595942 cites W2109755785 @default.
• W2759595942 cites W2127063807 @default.
• W2759595942 cites W2130206422 @default.
• W2759595942 cites W2130935482 @default.
• W2759595942 cites W2132350109 @default.
• W2759595942 cites W2133702185 @default.
• W2759595942 cites W2134138119 @default.
• W2759595942 cites W2135718124 @default.
• W2759595942 cites W2138012043 @default.
• W2759595942 cites W2140341433 @default.
• W2759595942 cites W2145100222 @default.
• W2759595942 cites W2145520412 @default.
• W2759595942 cites W2147044753 @default.
• W2759595942 cites W2150881469 @default.
• W2759595942 cites W2152695013 @default.
• W2759595942 cites W2154389993 @default.
• W2759595942 cites W2154700649 @default.
• W2759595942 cites W2159779491 @default.
• W2759595942 cites W2161225748 @default.
• W2759595942 cites W2163865122 @default.
• W2759595942 cites W2164540688 @default.
• W2759595942 cites W2166889104 @default.
• W2759595942 cites W2174162348 @default.
• W2759595942 cites W2296805285 @default.
• W2759595942 cites W2341709438 @default.
• W2759595942 cites W2345462336 @default.
• W2759595942 cites W2504479818 @default.
• W2759595942 cites W2515819507 @default.
• W2759595942 cites W2567228444 @default.
• W2759595942 cites W2567759662 @default.
• W2759595942 cites W2581820971 @default.
• W2759595942 cites W2593816418 @default.
• W2759595942 cites W2605743056 @default.
• W2759595942 cites W2658508676 @default.
• W2759595942 cites W2728853328 @default.
• W2759595942 cites W2740150675 @default.

• next