Matches in SemOpenAlex for { <https://semopenalex.org/work/W2759612414> ?p ?o ?g. }
- W2759612414 endingPage "148" @default.
- W2759612414 startingPage "143" @default.
- W2759612414 abstract "Autism Spectrum Disorders (ASD) are complex neurological disorders for which the prevalence in the U.S. is currently estimated to be 1 in 50 children. A majority of cases of idiopathic autism in children likely result from unknown environmental triggers in genetically susceptible individuals. These triggers may include maternal exposure of a developing embryo to environmentally relevant minute concentrations of psychoactive pharmaceuticals through ineffectively purified drinking water. Previous studies in our lab examined the extent to which gene sets associated with neuronal development were up- and down-regulated (enriched) in the brains of fathead minnows treated with psychoactive pharmaceuticals at environmental concentrations. The aim of this study was to determine whether similar treatments would alter in vitro expression of ASD-associated synaptic proteins on differentiated human neuronal cells. Human SK-N-SH neuroblastoma cells were differentiated for two weeks with 10μM retinoic acid (RA) and treated with environmentally relevant concentrations of fluoxetine, carbamazepine or venlafaxine, and flow cytometry technique was used to analyze expression of ASD-associated synaptic proteins. Data showed that carbamazepine individually, venlafaxine individually and mixture treatment at environmental concentrations significantly altered the expression of key synaptic proteins (NMDAR1, PSD95, SV2A, HTR1B, HTR2C and OXTR). Data indicated that psychoactive pharmaceuticals at extremely low concentrations altered the in vitro expression of key synaptic proteins that may potentially contribute to neurological disorders like ASD by disrupting neuronal development." @default.
- W2759612414 created "2017-10-06" @default.
- W2759612414 creator A5011892455 @default.
- W2759612414 creator A5018883043 @default.
- W2759612414 creator A5021261194 @default.
- W2759612414 creator A5034621627 @default.
- W2759612414 date "2017-11-01" @default.
- W2759612414 modified "2023-09-25" @default.
- W2759612414 title "Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations" @default.
- W2759612414 cites W1544632441 @default.
- W2759612414 cites W1563662593 @default.
- W2759612414 cites W1601872217 @default.
- W2759612414 cites W1973491179 @default.
- W2759612414 cites W1973880590 @default.
- W2759612414 cites W1982499768 @default.
- W2759612414 cites W2000873209 @default.
- W2759612414 cites W2009082639 @default.
- W2759612414 cites W2009776862 @default.
- W2759612414 cites W2011619507 @default.
- W2759612414 cites W2017408113 @default.
- W2759612414 cites W2027697114 @default.
- W2759612414 cites W2033436239 @default.
- W2759612414 cites W2037056332 @default.
- W2759612414 cites W2042368060 @default.
- W2759612414 cites W2043638322 @default.
- W2759612414 cites W2046865366 @default.
- W2759612414 cites W2047143817 @default.
- W2759612414 cites W2061660442 @default.
- W2759612414 cites W2062611904 @default.
- W2759612414 cites W2063867662 @default.
- W2759612414 cites W2073154969 @default.
- W2759612414 cites W2089978480 @default.
- W2759612414 cites W2093150351 @default.
- W2759612414 cites W2095898364 @default.
- W2759612414 cites W2102161750 @default.
- W2759612414 cites W2103590925 @default.
- W2759612414 cites W2122905516 @default.
- W2759612414 cites W2162729826 @default.
- W2759612414 cites W2163263839 @default.
- W2759612414 cites W2171854303 @default.
- W2759612414 cites W2283097177 @default.
- W2759612414 cites W2309085482 @default.
- W2759612414 cites W2341133005 @default.
- W2759612414 cites W2470991866 @default.
- W2759612414 cites W2577215016 @default.
- W2759612414 cites W2687519416 @default.
- W2759612414 doi "https://doi.org/10.1016/j.neulet.2017.09.058" @default.
- W2759612414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5695675" @default.
- W2759612414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28965935" @default.
- W2759612414 hasPublicationYear "2017" @default.
- W2759612414 type Work @default.
- W2759612414 sameAs 2759612414 @default.
- W2759612414 citedByCount "10" @default.
- W2759612414 countsByYear W27596124142018 @default.
- W2759612414 countsByYear W27596124142019 @default.
- W2759612414 countsByYear W27596124142020 @default.
- W2759612414 countsByYear W27596124142021 @default.
- W2759612414 countsByYear W27596124142022 @default.
- W2759612414 crossrefType "journal-article" @default.
- W2759612414 hasAuthorship W2759612414A5011892455 @default.
- W2759612414 hasAuthorship W2759612414A5018883043 @default.
- W2759612414 hasAuthorship W2759612414A5021261194 @default.
- W2759612414 hasAuthorship W2759612414A5034621627 @default.
- W2759612414 hasBestOaLocation W27596124142 @default.
- W2759612414 hasConcept C104317684 @default.
- W2759612414 hasConcept C118552586 @default.
- W2759612414 hasConcept C15744967 @default.
- W2759612414 hasConcept C169760540 @default.
- W2759612414 hasConcept C205778803 @default.
- W2759612414 hasConcept C2778538070 @default.
- W2759612414 hasConcept C2781121885 @default.
- W2759612414 hasConcept C54355233 @default.
- W2759612414 hasConcept C86803240 @default.
- W2759612414 hasConcept C98274493 @default.
- W2759612414 hasConceptScore W2759612414C104317684 @default.
- W2759612414 hasConceptScore W2759612414C118552586 @default.
- W2759612414 hasConceptScore W2759612414C15744967 @default.
- W2759612414 hasConceptScore W2759612414C169760540 @default.
- W2759612414 hasConceptScore W2759612414C205778803 @default.
- W2759612414 hasConceptScore W2759612414C2778538070 @default.
- W2759612414 hasConceptScore W2759612414C2781121885 @default.
- W2759612414 hasConceptScore W2759612414C54355233 @default.
- W2759612414 hasConceptScore W2759612414C86803240 @default.
- W2759612414 hasConceptScore W2759612414C98274493 @default.
- W2759612414 hasFunder F4320337354 @default.
- W2759612414 hasLocation W27596124141 @default.
- W2759612414 hasLocation W27596124142 @default.
- W2759612414 hasLocation W27596124143 @default.
- W2759612414 hasLocation W27596124144 @default.
- W2759612414 hasOpenAccess W2759612414 @default.
- W2759612414 hasPrimaryLocation W27596124141 @default.
- W2759612414 hasRelatedWork W2122849123 @default.
- W2759612414 hasRelatedWork W2332142175 @default.
- W2759612414 hasRelatedWork W2465370511 @default.
- W2759612414 hasRelatedWork W2593972102 @default.
- W2759612414 hasRelatedWork W2902352354 @default.
- W2759612414 hasRelatedWork W3107308995 @default.
- W2759612414 hasRelatedWork W3173150707 @default.