FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2759670081> ?p ?o ?g. }

• W2759670081 abstract "Domoic acid (DOM) is an excitatory amino acid analog of kainic acid (KA) that acts through glutamic acid (GLU) receptors, inducing a fast and potent neurotoxic response. Here, we present evidence for an enhancement of excitotoxicity following exposure of cultured cerebellar granule cells to DOM in the presence of lower than physiological Na+ concentrations. The concentration of DOM that reduced by 50% neuronal survival was approximately 3 µM in Na+-free conditions and 16 µM in presence of a physiological concentration of extracellular Na+. The enhanced neurotoxic effect of DOM was fully prevented by AMPA/KA receptor antagonist, while N-methyl-D-aspartate-receptor-mediated neurotoxicity did not seem to be involved, as the absence of extracellular Na+ failed to potentiate GLU excitotoxicity under the same experimental conditions. Lowering of extracellular Na+ concentration to 60 mM eliminated extracellular recording of spontaneous electrophysiological activity from cultured neurons grown on a multi electrode array and prevented DOM stimulation of the electrical activity. Although changes in the extracellular Na+ concentration did not alter the magnitude of the rapid increase in intracellular Ca2+ levels associated to DOM exposure, they did change significantly the contribution of voltage-sensitive calcium channels (VScaCs) and the recovery time to baseline. The prevention of Ca2+ influx via VSCaCs by nifedipine failed to prevent DOM toxicity at any extracellular Na+ concentration, while the reduction of extracellular Ca2+ concentration ameliorated DOM toxicity only in the absence of extracellular Na+, enhancing it in physiological conditions. Our data suggest a crucial role for extracellular Na+ concentration in determining excitotoxicity by DOM." @default.
• W2759670081 created "2017-10-06" @default.
• W2759670081 creator A5001040130 @default.
• W2759670081 creator A5002050482 @default.
• W2759670081 creator A5003062463 @default.
• W2759670081 creator A5031454261 @default.
• W2759670081 creator A5035014121 @default.
• W2759670081 creator A5057932605 @default.
• W2759670081 creator A5072077240 @default.
• W2759670081 date "2017-09-25" @default.
• W2759670081 modified "2023-09-26" @default.
• W2759670081 title "Selective Enhancement of Domoic Acid Toxicity in Primary Cultures of Cerebellar Granule Cells by Lowering Extracellular Na+ Concentration" @default.
• W2759670081 cites W1480568510 @default.
• W2759670081 cites W1622713230 @default.
• W2759670081 cites W1858901635 @default.
• W2759670081 cites W1965015552 @default.
• W2759670081 cites W1980044037 @default.
• W2759670081 cites W1980451075 @default.
• W2759670081 cites W1993370612 @default.
• W2759670081 cites W1995748948 @default.
• W2759670081 cites W1998547493 @default.
• W2759670081 cites W1999372723 @default.
• W2759670081 cites W2003534575 @default.
• W2759670081 cites W2008795665 @default.
• W2759670081 cites W2010657571 @default.
• W2759670081 cites W2012885259 @default.
• W2759670081 cites W2020043117 @default.
• W2759670081 cites W2020641072 @default.
• W2759670081 cites W2027700486 @default.
• W2759670081 cites W2030354892 @default.
• W2759670081 cites W2033822887 @default.
• W2759670081 cites W2037335023 @default.
• W2759670081 cites W2039978842 @default.
• W2759670081 cites W2043027376 @default.
• W2759670081 cites W2043364810 @default.
• W2759670081 cites W2043873927 @default.
• W2759670081 cites W2044897525 @default.
• W2759670081 cites W2045902521 @default.
• W2759670081 cites W2048345086 @default.
• W2759670081 cites W2048999009 @default.
• W2759670081 cites W2050049784 @default.
• W2759670081 cites W2051084778 @default.
• W2759670081 cites W2061540461 @default.
• W2759670081 cites W2062212141 @default.
• W2759670081 cites W2062681594 @default.
• W2759670081 cites W2068670803 @default.
• W2759670081 cites W2068994675 @default.
• W2759670081 cites W2075937507 @default.
• W2759670081 cites W2076109210 @default.
• W2759670081 cites W2077676422 @default.
• W2759670081 cites W2082249282 @default.
• W2759670081 cites W2084504852 @default.
• W2759670081 cites W2086888047 @default.
• W2759670081 cites W2087860815 @default.
• W2759670081 cites W2088139813 @default.
• W2759670081 cites W2095107574 @default.
• W2759670081 cites W2098324936 @default.
• W2759670081 cites W2108359586 @default.
• W2759670081 cites W2120105884 @default.
• W2759670081 cites W2128173061 @default.
• W2759670081 cites W2135619279 @default.
• W2759670081 cites W2143556838 @default.
• W2759670081 cites W2148095814 @default.
• W2759670081 cites W2167916525 @default.
• W2759670081 cites W2249444720 @default.
• W2759670081 cites W2337846333 @default.
• W2759670081 cites W2395058501 @default.
• W2759670081 cites W2584813339 @default.
• W2759670081 cites W4211235370 @default.
• W2759670081 cites W4238466651 @default.
• W2759670081 cites W4298150824 @default.
• W2759670081 cites W884397879 @default.
• W2759670081 doi "https://doi.org/10.1093/toxsci/kfx201" @default.
• W2759670081 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29029261" @default.
• W2759670081 hasPublicationYear "2017" @default.
• W2759670081 type Work @default.
• W2759670081 sameAs 2759670081 @default.
• W2759670081 citedByCount "4" @default.
• W2759670081 countsByYear W27596700812018 @default.
• W2759670081 countsByYear W27596700812019 @default.
• W2759670081 countsByYear W27596700812020 @default.
• W2759670081 crossrefType "journal-article" @default.
• W2759670081 hasAuthorship W2759670081A5001040130 @default.
• W2759670081 hasAuthorship W2759670081A5002050482 @default.
• W2759670081 hasAuthorship W2759670081A5003062463 @default.
• W2759670081 hasAuthorship W2759670081A5031454261 @default.
• W2759670081 hasAuthorship W2759670081A5035014121 @default.
• W2759670081 hasAuthorship W2759670081A5057932605 @default.
• W2759670081 hasAuthorship W2759670081A5072077240 @default.
• W2759670081 hasBestOaLocation W27596700811 @default.
• W2759670081 hasConcept C12554922 @default.
• W2759670081 hasConcept C160268369 @default.
• W2759670081 hasConcept C170493617 @default.
• W2759670081 hasConcept C178790620 @default.
• W2759670081 hasConcept C185592680 @default.
• W2759670081 hasConcept C2776108384 @default.
• W2759670081 hasConcept C2776314819 @default.
• W2759670081 hasConcept C2777367657 @default.
• W2759670081 hasConcept C2779491297 @default.
• W2759670081 hasConcept C2781012912 @default.

• next