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- W2759673056 endingPage "e0185107" @default.
- W2759673056 startingPage "e0185107" @default.
- W2759673056 abstract "Calcium binding proteins show stereotypical expression patterns within diverse neuron types across the central nervous system. Here, we provide a characterization of developmental and adult secretagogin-immunolabelled neurons in the zebrafish retina with an emphasis on co-expression of multiple calcium binding proteins. Secretagogin is a recently identified and cloned member of the F-hand family of calcium binding proteins, which labels distinct neuron populations in the retinas of mammalian vertebrates. Both the adult distribution of secretagogin labeled retinal neurons as well as the developmental expression indicative of the stage of neurogenesis during which this calcium binding protein is expressed was quantified. Secretagogin expression was confined to an amacrine interneuron population in the inner nuclear layer, with monostratified neurites in the center of the inner plexiform layer and a relatively regular soma distribution (regularity index > 2.5 across central–peripheral areas). However, only a subpopulation (~60%) co-labeled with gamma-aminobutyric acid as their neurotransmitter, suggesting that possibly two amacrine subtypes are secretagogin immunoreactive. Quantitative co-labeling analysis with other known amacrine subtype markers including the three main calcium binding proteins parvalbumin, calbindin and calretinin identifies secretagogin immunoreactive neurons as a distinct neuron population. The highest density of secretagogin cells of ~1800 cells / mm2 remained relatively evenly along the horizontal meridian, whilst the density dropped of to 125 cells / mm2 towards the dorsal and ventral periphery. Thus, secretagogin represents a new amacrine label within the zebrafish retina. The developmental expression suggests a possible role in late stage differentiation. This characterization forms the basis of functional studies assessing how the expression of distinct calcium binding proteins might be regulated to compensate for the loss of one of the others." @default.
- W2759673056 created "2017-10-06" @default.
- W2759673056 creator A5008498977 @default.
- W2759673056 creator A5029395389 @default.
- W2759673056 creator A5044401650 @default.
- W2759673056 date "2017-09-26" @default.
- W2759673056 modified "2023-10-11" @default.
- W2759673056 title "Developmental and adult characterization of secretagogin expressing amacrine cells in zebrafish retina" @default.
- W2759673056 cites W1511705190 @default.
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- W2759673056 cites W1765049112 @default.
- W2759673056 cites W1817006636 @default.
- W2759673056 cites W1963740481 @default.
- W2759673056 cites W1966286330 @default.
- W2759673056 cites W1967170509 @default.
- W2759673056 cites W1980883732 @default.
- W2759673056 cites W1989248578 @default.
- W2759673056 cites W1989918632 @default.
- W2759673056 cites W1990374910 @default.
- W2759673056 cites W1995813931 @default.
- W2759673056 cites W1996866955 @default.
- W2759673056 cites W2002424278 @default.
- W2759673056 cites W2003100222 @default.
- W2759673056 cites W2004042165 @default.
- W2759673056 cites W2008027377 @default.
- W2759673056 cites W2008813184 @default.
- W2759673056 cites W2009828191 @default.
- W2759673056 cites W2015836446 @default.
- W2759673056 cites W2018467317 @default.
- W2759673056 cites W2020397575 @default.
- W2759673056 cites W2024661068 @default.
- W2759673056 cites W2025658876 @default.
- W2759673056 cites W2029390749 @default.
- W2759673056 cites W2033773969 @default.
- W2759673056 cites W2034656159 @default.
- W2759673056 cites W2040176167 @default.
- W2759673056 cites W2041558551 @default.
- W2759673056 cites W2045535542 @default.
- W2759673056 cites W2048057151 @default.
- W2759673056 cites W2060589548 @default.
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- W2759673056 cites W2075922779 @default.
- W2759673056 cites W2078243293 @default.
- W2759673056 cites W2080003383 @default.
- W2759673056 cites W2082909640 @default.
- W2759673056 cites W2087147760 @default.
- W2759673056 cites W2088115070 @default.
- W2759673056 cites W2090132302 @default.
- W2759673056 cites W2091212902 @default.
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- W2759673056 cites W2096910283 @default.
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- W2759673056 cites W2126960321 @default.
- W2759673056 cites W2131577885 @default.
- W2759673056 cites W2137665815 @default.
- W2759673056 cites W2138867635 @default.
- W2759673056 cites W2143694949 @default.
- W2759673056 cites W2147666897 @default.
- W2759673056 cites W2151788312 @default.
- W2759673056 cites W2154050646 @default.
- W2759673056 cites W2154150265 @default.
- W2759673056 cites W2156625231 @default.
- W2759673056 cites W2163750597 @default.
- W2759673056 cites W2166425307 @default.
- W2759673056 cites W2168505250 @default.
- W2759673056 cites W2188078935 @default.
- W2759673056 cites W2274398477 @default.
- W2759673056 cites W2409374583 @default.
- W2759673056 cites W2514488636 @default.
- W2759673056 cites W2524585287 @default.
- W2759673056 cites W2567482528 @default.
- W2759673056 cites W2586752289 @default.
- W2759673056 cites W2589408026 @default.
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- W2759673056 doi "https://doi.org/10.1371/journal.pone.0185107" @default.
- W2759673056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5614429" @default.
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- W2759673056 hasPublicationYear "2017" @default.
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