Matches in SemOpenAlex for { <https://semopenalex.org/work/W2759969893> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2759969893 endingPage "1437" @default.
- W2759969893 startingPage "1430" @default.
- W2759969893 abstract "Collagenase Clostridium histolyticum (CCH) is indicated for the treatment of penile curvature in adult men with Peyronie's disease (PD) with palpable plaque and curvature deformity of at least 30° at the start of therapy.To evaluate the efficacy and safety of CCH plus vacuum-pump therapy with and without penile modeling for the management of PD.Adult men with PD and penile curvature of at least 30° were randomly assigned to receive CCH 0.58 mg plus vacuum therapy alone (n = 15) or with penile plaque modeling (n = 15). Patients received no more than four treatment cycles (cycle = ∼6-week duration), each consisting of two intralesional injections of CCH administered 24 to 72 hours apart. Vacuum therapy was applied twice daily from 14 days after the second injection of each cycle until the following cycle. Modeling was performed 24 to 72 hours after the second injection of each cycle.The primary end point was change in penile curvature from baseline to week 36; additional end points included changes in Peyronie's Disease Questionnaire (PDQ) domain scores, composite response (≥20% decrease in penile curvature and decrease in PDQ bother score ≥ 1 point), and global response (small but important, moderate, or much improvement in the Global Assessment of PD).At week 36, improvement in penile curvature from baseline was similar in the two groups (mean change from baseline = -23.7° [SD = 10.9] for CCH + vacuum + modeling and -23.3° [SD = 7.2] for CCH + vacuum; between-group difference = -0.3°, 95% CI = -7.3 to 6.6). Improvements in most PDQ domains, including bother, were observed from baseline to week 36 in the two groups. Most patients were composite (66.7% and 84.6% with CCH + vacuum + modeling and CCH + vacuum, respectively) and global (86.7% and 92.3%, respectively) responders. The most common adverse events were penile contusion, penile swelling, and penile pain.Vacuum-pump therapy administered alone or in combination with modeling after CCH treatment could improve PD symptoms.This was a pilot study with a small sample and limited follow-up duration.CCH and vacuum-pump therapy (alone or combined with modeling) could be an appropriate consideration for men with PD and warrants further investigation. Ralph DJ, Abdel Raheem A, Liu G. Treatment of Peyronie's Disease With Collagenase Clostridium histolyticum and Vacuum Therapy: A Randomized, Open-Label Pilot Study. J Sex Med 2017;14:1430-1437." @default.
- W2759969893 created "2017-10-06" @default.
- W2759969893 creator A5045209885 @default.
- W2759969893 creator A5057582456 @default.
- W2759969893 creator A5075896958 @default.
- W2759969893 date "2017-11-01" @default.
- W2759969893 modified "2023-10-12" @default.
- W2759969893 title "Treatment of Peyronie's Disease With Collagenase Clostridium histolyticum and Vacuum Therapy: A Randomized, Open-Label Pilot Study" @default.
- W2759969893 cites W2005278720 @default.
- W2759969893 cites W2066529420 @default.
- W2759969893 cites W2086240335 @default.
- W2759969893 cites W2155541418 @default.
- W2759969893 cites W2941255854 @default.
- W2759969893 doi "https://doi.org/10.1016/j.jsxm.2017.08.015" @default.
- W2759969893 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28974406" @default.
- W2759969893 hasPublicationYear "2017" @default.
- W2759969893 type Work @default.
- W2759969893 sameAs 2759969893 @default.
- W2759969893 citedByCount "32" @default.
- W2759969893 countsByYear W27599698932018 @default.
- W2759969893 countsByYear W27599698932019 @default.
- W2759969893 countsByYear W27599698932020 @default.
- W2759969893 countsByYear W27599698932021 @default.
- W2759969893 countsByYear W27599698932022 @default.
- W2759969893 countsByYear W27599698932023 @default.
- W2759969893 crossrefType "journal-article" @default.
- W2759969893 hasAuthorship W2759969893A5045209885 @default.
- W2759969893 hasAuthorship W2759969893A5057582456 @default.
- W2759969893 hasAuthorship W2759969893A5075896958 @default.
- W2759969893 hasBestOaLocation W27599698931 @default.
- W2759969893 hasConcept C126322002 @default.
- W2759969893 hasConcept C126894567 @default.
- W2759969893 hasConcept C141071460 @default.
- W2759969893 hasConcept C181199279 @default.
- W2759969893 hasConcept C185592680 @default.
- W2759969893 hasConcept C2778394429 @default.
- W2759969893 hasConcept C2779145901 @default.
- W2759969893 hasConcept C2779929075 @default.
- W2759969893 hasConcept C3018271632 @default.
- W2759969893 hasConcept C55493867 @default.
- W2759969893 hasConcept C71924100 @default.
- W2759969893 hasConceptScore W2759969893C126322002 @default.
- W2759969893 hasConceptScore W2759969893C126894567 @default.
- W2759969893 hasConceptScore W2759969893C141071460 @default.
- W2759969893 hasConceptScore W2759969893C181199279 @default.
- W2759969893 hasConceptScore W2759969893C185592680 @default.
- W2759969893 hasConceptScore W2759969893C2778394429 @default.
- W2759969893 hasConceptScore W2759969893C2779145901 @default.
- W2759969893 hasConceptScore W2759969893C2779929075 @default.
- W2759969893 hasConceptScore W2759969893C3018271632 @default.
- W2759969893 hasConceptScore W2759969893C55493867 @default.
- W2759969893 hasConceptScore W2759969893C71924100 @default.
- W2759969893 hasIssue "11" @default.
- W2759969893 hasLocation W27599698931 @default.
- W2759969893 hasLocation W27599698932 @default.
- W2759969893 hasLocation W27599698933 @default.
- W2759969893 hasLocation W27599698934 @default.
- W2759969893 hasOpenAccess W2759969893 @default.
- W2759969893 hasPrimaryLocation W27599698931 @default.
- W2759969893 hasRelatedWork W165262246 @default.
- W2759969893 hasRelatedWork W1965286332 @default.
- W2759969893 hasRelatedWork W2072116700 @default.
- W2759969893 hasRelatedWork W2171098927 @default.
- W2759969893 hasRelatedWork W2327716609 @default.
- W2759969893 hasRelatedWork W2339703265 @default.
- W2759969893 hasRelatedWork W2759969893 @default.
- W2759969893 hasRelatedWork W2891454266 @default.
- W2759969893 hasRelatedWork W3116894593 @default.
- W2759969893 hasRelatedWork W2281914468 @default.
- W2759969893 hasVolume "14" @default.
- W2759969893 isParatext "false" @default.
- W2759969893 isRetracted "false" @default.
- W2759969893 magId "2759969893" @default.
- W2759969893 workType "article" @default.