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- W2760091959 abstract "The reductive (1 + 4) annulation reaction of isatins and substituted nitroalkenes mediated by a trivalent phosphorus reagent has been realized for the first time, providing easy access to spirooxindolyl isoxazoline N-oxides in moderate to excellent yields with a flexible substrate scope. This reaction presumably proceeds through a Michael addition-intramolecular substitution sequence via active in situ generated Kukhtin-Ramirez zwitterions from isatins and P(NMe2)3. It is also demonstrated that the spirooxindolyl isoxazoline N-oxides can be readily converted into the corresponding isoxazolines in good yields." @default.
- W2760091959 created "2017-10-06" @default.
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- W2760091959 date "2017-10-06" @default.
- W2760091959 modified "2023-10-17" @default.
- W2760091959 title "P(NMe<sub>2</sub>)<sub>3</sub>-Mediated Reductive (1 + 4) Annulation Reaction of Isatins with Nitroalkenes: An Access to Spirooxindolyl Isoxazoline <i>N</i>-Oxides and Their Corresponding Isoxazolines" @default.
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- W2760091959 doi "https://doi.org/10.1021/acs.joc.7b01962" @default.
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