FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2760147779> ?p ?o ?g. }

• W2760147779 endingPage "105" @default.
• W2760147779 startingPage "96" @default.
• W2760147779 abstract "We evaluated the effect of six azoles on embryonic development in the rat whole embryo culture (WEC). Using the total morphological scoring system (TMS), we calculated the ID10 concentration (effective dose for 10% decrease in TMS). For evaluating gene specific responses, we combined previously and newly collected transcriptomics data of rat WEC exposed to a total of twelve azoles at their ID10 for 4 h. Results revealed shared expressions responses in genes involved in the retinoic acid (RA) and sterol biosynthesis pathways, which are respectively representatives of developmental toxicity and targeted fungicidal action of the azoles. Azoles with more pronounced effects on the regulation of RA-associated genes were generally characterized as more potent embryotoxicants. Overall, compounds with strong sterol biosynthesis related responses and low RA related responses were considered as more favourable candidates, as they specifically regulated genes related to a desired target response. Among the identified sterol associated genes, we detected that methylsterol monooxygenase 1 (Msmo1) was more sensitively induced compared to Cyp51, a classical biomarker of this pathway. Therefore, we suggest that Msmo1 could be a better biomarker for screening the fungicidal value of azoles. In summary, we conclude that the embryonic regulation of RA and sterol metabolic pathways could be indicators for ranking azoles as embryotoxicants and determining their drug efficacy." @default.
• W2760147779 created "2017-10-06" @default.
• W2760147779 creator A5005695098 @default.
• W2760147779 creator A5010620767 @default.
• W2760147779 creator A5032367534 @default.
• W2760147779 creator A5032681578 @default.
• W2760147779 creator A5064793035 @default.
• W2760147779 creator A5071796957 @default.
• W2760147779 date "2017-12-01" @default.
• W2760147779 modified "2023-09-24" @default.
• W2760147779 title "A transcriptomic approach for evaluating the relative potency and mechanism of action of azoles in the rat Whole Embryo Culture" @default.
• W2760147779 cites W1508438515 @default.
• W2760147779 cites W1771341671 @default.
• W2760147779 cites W1891305169 @default.
• W2760147779 cites W1961499381 @default.
• W2760147779 cites W1973087247 @default.
• W2760147779 cites W1975805528 @default.
• W2760147779 cites W1987427115 @default.
• W2760147779 cites W1990492545 @default.
• W2760147779 cites W1990711550 @default.
• W2760147779 cites W1992215377 @default.
• W2760147779 cites W1995137212 @default.
• W2760147779 cites W2006007751 @default.
• W2760147779 cites W2010850871 @default.
• W2760147779 cites W2015192752 @default.
• W2760147779 cites W2025651276 @default.
• W2760147779 cites W2029115838 @default.
• W2760147779 cites W2029930882 @default.
• W2760147779 cites W2033183212 @default.
• W2760147779 cites W2035976525 @default.
• W2760147779 cites W2037851943 @default.
• W2760147779 cites W2047040382 @default.
• W2760147779 cites W2054706055 @default.
• W2760147779 cites W2060954164 @default.
• W2760147779 cites W2063657209 @default.
• W2760147779 cites W2077423081 @default.
• W2760147779 cites W2081105512 @default.
• W2760147779 cites W2084176144 @default.
• W2760147779 cites W2091022202 @default.
• W2760147779 cites W2103078752 @default.
• W2760147779 cites W2106136854 @default.
• W2760147779 cites W2112260651 @default.
• W2760147779 cites W2125786873 @default.
• W2760147779 cites W2126997165 @default.
• W2760147779 cites W2128091448 @default.
• W2760147779 cites W2135827569 @default.
• W2760147779 cites W2136038893 @default.
• W2760147779 cites W2145797337 @default.
• W2760147779 cites W2146076820 @default.
• W2760147779 cites W2158217645 @default.
• W2760147779 cites W2163112976 @default.
• W2760147779 cites W2170989872 @default.
• W2760147779 cites W2171949723 @default.
• W2760147779 cites W2341649225 @default.
• W2760147779 cites W2414622870 @default.
• W2760147779 cites W2465897804 @default.
• W2760147779 cites W2594159580 @default.
• W2760147779 cites W2606675097 @default.
• W2760147779 cites W2621082962 @default.
• W2760147779 doi "https://doi.org/10.1016/j.tox.2017.09.014" @default.
• W2760147779 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28970091" @default.
• W2760147779 hasPublicationYear "2017" @default.
• W2760147779 type Work @default.
• W2760147779 sameAs 2760147779 @default.
• W2760147779 citedByCount "9" @default.
• W2760147779 countsByYear W27601477792018 @default.
• W2760147779 countsByYear W27601477792019 @default.
• W2760147779 countsByYear W27601477792020 @default.
• W2760147779 countsByYear W27601477792021 @default.
• W2760147779 countsByYear W27601477792022 @default.
• W2760147779 crossrefType "journal-article" @default.
• W2760147779 hasAuthorship W2760147779A5005695098 @default.
• W2760147779 hasAuthorship W2760147779A5010620767 @default.
• W2760147779 hasAuthorship W2760147779A5032367534 @default.
• W2760147779 hasAuthorship W2760147779A5032681578 @default.
• W2760147779 hasAuthorship W2760147779A5064793035 @default.
• W2760147779 hasAuthorship W2760147779A5071796957 @default.
• W2760147779 hasBestOaLocation W27601477791 @default.
• W2760147779 hasConcept C104317684 @default.
• W2760147779 hasConcept C150194340 @default.
• W2760147779 hasConcept C162317418 @default.
• W2760147779 hasConcept C178790620 @default.
• W2760147779 hasConcept C181199279 @default.
• W2760147779 hasConcept C185592680 @default.
• W2760147779 hasConcept C196843134 @default.
• W2760147779 hasConcept C202751555 @default.
• W2760147779 hasConcept C2776120743 @default.
• W2760147779 hasConcept C2778163477 @default.
• W2760147779 hasConcept C2778718757 @default.
• W2760147779 hasConcept C2781121885 @default.
• W2760147779 hasConcept C29730261 @default.
• W2760147779 hasConcept C526171541 @default.
• W2760147779 hasConcept C55493867 @default.
• W2760147779 hasConcept C57992300 @default.
• W2760147779 hasConcept C86803240 @default.
• W2760147779 hasConcept C93231420 @default.
• W2760147779 hasConcept C95444343 @default.
• W2760147779 hasConcept C98274493 @default.

• next