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• W2760160246 abstract "Thymoquinone (2-methyl-5-isopropyl-1, 4-benzoquinone-TQ) is chemically a monoterpene extracted from Nigella sativa L. seed oil (Ranunculaceae) commonly known as black cumin seed. The rigorous studies have revealed that thymoquinone the major active constituent of Nigella sativa oil brings to bear majority of pharmacological actions such as anti-inflammatory, anti-oxidant, anti-diabetic and organ-protective activities. Thymoquinone is a potent phytochemical with confirmed in-vitro efficacy used for several treatment purposes. The vast studies have revealed diverse molecular pathways of nearly all major diseases. Belonging to a phytochemical group, TQ is observed as strong lipophilic constituent hence insolubility in aqueous fluids hamper its systemic bioavailability. Hence, the physiochemical parameters and the associated toxicities are the barrier for the researchers using TQ clinically. Further studies revealed that TQ is highly light and heat sensitive, which obstruct the successful formulation for the delivery of drug. The present review aims to provide insights regarding the characteristics, pharmacokinetics and targets associated with the use of TQ in different pharmacological actions. It also suggests methods to improve the use of TQ by overcoming the associated physiochemical obstacles and the related toxicities and best utilisation for animal as well as clinical studies. According to the published reports of TQ, we suggest in-depth studies regarding the bioavailability and toxicity studies in animals as well as in humans." @default.
• W2760160246 created "2017-10-06" @default.
• W2760160246 creator A5008387075 @default.
• W2760160246 creator A5015791582 @default.
• W2760160246 creator A5032552315 @default.
• W2760160246 creator A5056584390 @default.
• W2760160246 creator A5063029157 @default.
• W2760160246 creator A5069563237 @default.
• W2760160246 creator A5075054507 @default.
• W2760160246 date "2017-09-21" @default.
• W2760160246 modified "2023-10-18" @default.
• W2760160246 title "Therapeutic Potential and Pharmaceutical Development of Thymoquinone: A Multitargeted Molecule of Natural Origin" @default.
• W2760160246 cites W1263584737 @default.
• W2760160246 cites W1264884259 @default.
• W2760160246 cites W131953911 @default.
• W2760160246 cites W137431429 @default.
• W2760160246 cites W1493557897 @default.
• W2760160246 cites W1498106732 @default.
• W2760160246 cites W1507809553 @default.
• W2760160246 cites W1547179741 @default.
• W2760160246 cites W1559349803 @default.
• W2760160246 cites W1586597239 @default.
• W2760160246 cites W1674841587 @default.
• W2760160246 cites W1815431626 @default.
• W2760160246 cites W1820449832 @default.
• W2760160246 cites W1853321321 @default.
• W2760160246 cites W1964200179 @default.
• W2760160246 cites W1964663548 @default.
• W2760160246 cites W1965700294 @default.
• W2760160246 cites W1966797392 @default.
• W2760160246 cites W1967456541 @default.
• W2760160246 cites W1970471812 @default.
• W2760160246 cites W1970547610 @default.
• W2760160246 cites W1973424434 @default.
• W2760160246 cites W1974785158 @default.
• W2760160246 cites W1975375696 @default.
• W2760160246 cites W1975494729 @default.
• W2760160246 cites W1975836615 @default.
• W2760160246 cites W1976535708 @default.
• W2760160246 cites W1976902773 @default.
• W2760160246 cites W1977681279 @default.
• W2760160246 cites W1977681992 @default.
• W2760160246 cites W1982294158 @default.
• W2760160246 cites W1984071966 @default.
• W2760160246 cites W1985021873 @default.
• W2760160246 cites W1987704691 @default.
• W2760160246 cites W1987992684 @default.
• W2760160246 cites W1988336925 @default.
• W2760160246 cites W1988573625 @default.
• W2760160246 cites W1989524688 @default.
• W2760160246 cites W1993288305 @default.
• W2760160246 cites W1994174907 @default.
• W2760160246 cites W199878420 @default.
• W2760160246 cites W2000408764 @default.
• W2760160246 cites W2002484202 @default.
• W2760160246 cites W2004209271 @default.
• W2760160246 cites W2007888214 @default.
• W2760160246 cites W2009295553 @default.
• W2760160246 cites W2010785953 @default.
• W2760160246 cites W2012913773 @default.
• W2760160246 cites W2013305198 @default.
• W2760160246 cites W2013628667 @default.
• W2760160246 cites W2013785469 @default.
• W2760160246 cites W2014555168 @default.
• W2760160246 cites W2015050458 @default.
• W2760160246 cites W2016903551 @default.
• W2760160246 cites W2017072882 @default.
• W2760160246 cites W2017696631 @default.
• W2760160246 cites W2017812837 @default.
• W2760160246 cites W2019467534 @default.
• W2760160246 cites W2020286683 @default.
• W2760160246 cites W2020755939 @default.
• W2760160246 cites W2021354272 @default.
• W2760160246 cites W2022174018 @default.
• W2760160246 cites W2023647276 @default.
• W2760160246 cites W2024125890 @default.
• W2760160246 cites W2026428353 @default.
• W2760160246 cites W2028746380 @default.
• W2760160246 cites W2029751460 @default.
• W2760160246 cites W2031630499 @default.
• W2760160246 cites W2031940639 @default.
• W2760160246 cites W2035522682 @default.
• W2760160246 cites W2035966584 @default.
• W2760160246 cites W2038411346 @default.
• W2760160246 cites W2039061128 @default.
• W2760160246 cites W2040501773 @default.
• W2760160246 cites W2041887393 @default.
• W2760160246 cites W2045269236 @default.
• W2760160246 cites W2048341129 @default.
• W2760160246 cites W2048649776 @default.
• W2760160246 cites W2050640675 @default.
• W2760160246 cites W2051186292 @default.
• W2760160246 cites W2052356211 @default.
• W2760160246 cites W2053582578 @default.
• W2760160246 cites W2056653443 @default.
• W2760160246 cites W2057809866 @default.
• W2760160246 cites W2058812990 @default.
• W2760160246 cites W2060043755 @default.
• W2760160246 cites W2061554874 @default.
• W2760160246 cites W2061868762 @default.

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