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- W2760403647 endingPage "2294" @default.
- W2760403647 startingPage "2274" @default.
- W2760403647 abstract "Atrial fibrillation (AF) is associated with significant risk of stroke and other thromboembolic events, which can be effectively prevented using oral anticoagulation (OAC) with either vitamin K antagonists (VKAs) or non-VKA oral anticoagulants (NOACs) dabigatran, rivaroxaban, apixaban, or edoxaban. Until recently, VKAs were the only available means for OAC treatment. NOACs had similar efficacy and were safer than or as safe as warfarin with respect to reduced rates of hemorrhagic stroke or other intracranial bleeding in the respective pivotal randomized clinical trials (RCTs) of stroke prevention in non-valvular AF patients. Increasing “real-world” evidence on NOACs broadly confirms the results of the RCTs. However, individual patient characteristics including renal function, age, or prior bleeding should be taken into account when choosing the OAC with best risk–benefit profile. In patients ineligible for OACs, surgical or interventional stroke prevention strategies should be considered. In patients undergoing cardiac surgery for other reasons, the left atrial appendage excision, ligation, or amputation may be the best option. Importantly, residual stumps or insufficient ligation may result in even higher stroke risk than without intervention. Percutaneous left atrial appendage occlusion, although requiring minimally invasive access, failed to demonstrate reduced ischemic stroke events compared to warfarin. In this review article, we summarize current treatment options and discuss the strengths and major limitations of the therapies for stroke risk reduction in patients with AF." @default.
- W2760403647 created "2017-10-06" @default.
- W2760403647 creator A5024354264 @default.
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- W2760403647 creator A5068179532 @default.
- W2760403647 creator A5068566870 @default.
- W2760403647 creator A5069036914 @default.
- W2760403647 date "2017-09-27" @default.
- W2760403647 modified "2023-10-05" @default.
- W2760403647 title "Pharmacological and Non-pharmacological Treatments for Stroke Prevention in Patients with Atrial Fibrillation" @default.
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