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• W2760457939 abstract "// Theresa Benezeder 1 , Verena Tiran 1 , Alexandra A.N. Treitler 1 , Christoph Suppan 1 , Christopher Rossmann 1 , Herbert Stoeger 1 , Richard J. Cote 2 , Ram H. Datar 2 , Marija Balic 1, 3 and Nadia Dandachi 1, 4 1 Medical University of Graz, Department of Internal Medicine, Division of Oncology, Graz, Austria 2 University of Miami Miller School of Medicine, Department of Pathology, Miami, Florida, U.S.A. 3 Medical University of Graz, Research Unit Circulating Tumor Cells and Cancer Stem Cells, Graz, Austria 4 Medical University of Graz, Research Unit Epigenetic and Genetic Cancer Biomarkers, Division of Oncology, Graz, Austria Correspondence to: Nadia Dandachi, email: nadia.dandachi@medunigraz.at Marija Balic, email: marija.balic@medunigraz.at Keywords: circulating tumor cells, enrichment, metastatic breast cancer, methylation, prognosis Received: April 12, 2017      Accepted: August 27, 2017      Published: September 30, 2017 ABSTRACT Blood-based biomarkers such as circulating tumor cells (CTCs) provide dynamic real-time assessment of molecular tumor characteristics beyond the primary tumor. The aim of this study was to evaluate the feasibility of a size-based microfilter to assess multigene methylation analysis of enriched CTCs in a prospective proof-of principle study. We examined the quantitative methylation status of nine genes ( AKR1B1, BMP6, CST6, HOXB4, HIST1H3C, ITIH5, NEUROD1, RASSF1, SOX17 ) in enriched CTCs from metastatic breast cancer patients. Feasibility and clinical performance testing were assessed in a test set consisting of 37 patients and 25 healthy controls. With established cut-off values from the healthy control group, methylation of enriched CTCs was detected in at least one gene in 18/37 patients (48.6%), while 97.8% of all control samples were unmethylated. Patients with CTCs unmethylated for CST6 , ITIH5 , or RASSF1 showed significantly longer PFS compared to patients with corresponding enriched methylated CTCs. This proof-of-principle study shows the feasibility of a size-based microfilter to enrich and analyze multigene methylation profile of CTCs from metastatic breast cancer patients. For the first time, we report that multigene methylation analysis of enriched CTCs provides prognostic information in metastatic breast cancer patients." @default.
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• W2760457939 date "2017-09-30" @default.
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• W2760457939 title "Multigene methylation analysis of enriched circulating tumor cells associates with poor progression-free survival in metastatic breast cancer patients" @default.
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• W2760457939 doi "https://doi.org/10.18632/oncotarget.21426" @default.
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