FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2760587614> ?p ?o ?g. }

• W2760587614 endingPage "331" @default.
• W2760587614 startingPage "323" @default.
• W2760587614 abstract "Considerable advances in understanding the protein features favoring prion formation in yeast have facilitated the development of effective yeast prion prediction algorithms. Here we discuss a recent study in which we systematically explored the utility of the yeast prion prediction algorithm PAPA for designing mutations to modulate the aggregation activity of the human prion-like protein hnRNPA2B1. Mutations in hnRNPA2B1 cause multisystem proteinopathy in humans, and accelerate aggregation of the protein in vitro. Additionally, mutant hnRNPA2B1 forms cytoplasmic inclusions when expressed in Drosophila, and the mutant prion-like domain can substitute for a portion of a yeast prion domain in supporting prion activity in yeast. PAPA was quite successful at predicting the effects of PrLD mutations on prion activity in yeast and on in vitro aggregation propensity. Additionally, PAPA successfully predicted the effects of most, but not all, mutations in the PrLD of the hnRNPA2B1 protein when expressed in Drosophila. These results suggest that PAPA is quite effective at predicting the effects of mutations on intrinsic aggregation propensity, but that intracellular factors can influence aggregation and prion-like activity in vivo. A more complete understanding of these intracellular factors may inform the next generation of prion prediction algorithms." @default.
• W2760587614 created "2017-10-06" @default.
• W2760587614 creator A5039932649 @default.
• W2760587614 creator A5067205503 @default.
• W2760587614 creator A5087578611 @default.
• W2760587614 date "2017-09-03" @default.
• W2760587614 modified "2023-10-11" @default.
• W2760587614 title "Manipulating the aggregation activity of human prion-like proteins" @default.
• W2760587614 cites W1481393922 @default.
• W2760587614 cites W1580609715 @default.
• W2760587614 cites W1601640901 @default.
• W2760587614 cites W1965286266 @default.
• W2760587614 cites W1968726777 @default.
• W2760587614 cites W1977034658 @default.
• W2760587614 cites W1983722036 @default.
• W2760587614 cites W2006934202 @default.
• W2760587614 cites W2009603911 @default.
• W2760587614 cites W2013145010 @default.
• W2760587614 cites W2027839322 @default.
• W2760587614 cites W2033833965 @default.
• W2760587614 cites W2035928222 @default.
• W2760587614 cites W2050207511 @default.
• W2760587614 cites W2056215835 @default.
• W2760587614 cites W2064560754 @default.
• W2760587614 cites W2075186362 @default.
• W2760587614 cites W2100383597 @default.
• W2760587614 cites W2105148157 @default.
• W2760587614 cites W2112650804 @default.
• W2760587614 cites W2129507901 @default.
• W2760587614 cites W2129602427 @default.
• W2760587614 cites W2132121416 @default.
• W2760587614 cites W2139066576 @default.
• W2760587614 cites W2139995722 @default.
• W2760587614 cites W2146865209 @default.
• W2760587614 cites W2146926661 @default.
• W2760587614 cites W2149541702 @default.
• W2760587614 cites W2150860983 @default.
• W2760587614 cites W2152231829 @default.
• W2760587614 cites W2168639701 @default.
• W2760587614 cites W2169665392 @default.
• W2760587614 cites W2177779309 @default.
• W2760587614 cites W2316459248 @default.
• W2760587614 cites W2338081764 @default.
• W2760587614 cites W2466864989 @default.
• W2760587614 cites W2474938401 @default.
• W2760587614 cites W2547881573 @default.
• W2760587614 cites W2556818673 @default.
• W2760587614 cites W2560876368 @default.
• W2760587614 cites W2580158211 @default.
• W2760587614 cites W2605586296 @default.
• W2760587614 cites W2618696667 @default.
• W2760587614 doi "https://doi.org/10.1080/19336896.2017.1356560" @default.
• W2760587614 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5639851" @default.
• W2760587614 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28934062" @default.
• W2760587614 hasPublicationYear "2017" @default.
• W2760587614 type Work @default.
• W2760587614 sameAs 2760587614 @default.
• W2760587614 citedByCount "8" @default.
• W2760587614 countsByYear W27605876142018 @default.
• W2760587614 countsByYear W27605876142019 @default.
• W2760587614 countsByYear W27605876142020 @default.
• W2760587614 countsByYear W27605876142021 @default.
• W2760587614 countsByYear W27605876142022 @default.
• W2760587614 countsByYear W27605876142023 @default.
• W2760587614 crossrefType "journal-article" @default.
• W2760587614 hasAuthorship W2760587614A5039932649 @default.
• W2760587614 hasAuthorship W2760587614A5067205503 @default.
• W2760587614 hasAuthorship W2760587614A5087578611 @default.
• W2760587614 hasBestOaLocation W27605876141 @default.
• W2760587614 hasConcept C104317684 @default.
• W2760587614 hasConcept C118963712 @default.
• W2760587614 hasConcept C136238340 @default.
• W2760587614 hasConcept C142724271 @default.
• W2760587614 hasConcept C143065580 @default.
• W2760587614 hasConcept C185592680 @default.
• W2760587614 hasConcept C190062978 @default.
• W2760587614 hasConcept C19843653 @default.
• W2760587614 hasConcept C202751555 @default.
• W2760587614 hasConcept C2777576037 @default.
• W2760587614 hasConcept C2779134260 @default.
• W2760587614 hasConcept C2779222958 @default.
• W2760587614 hasConcept C3019804061 @default.
• W2760587614 hasConcept C501734568 @default.
• W2760587614 hasConcept C55493867 @default.
• W2760587614 hasConcept C71924100 @default.
• W2760587614 hasConcept C79879829 @default.
• W2760587614 hasConcept C86803240 @default.
• W2760587614 hasConcept C95444343 @default.
• W2760587614 hasConceptScore W2760587614C104317684 @default.
• W2760587614 hasConceptScore W2760587614C118963712 @default.
• W2760587614 hasConceptScore W2760587614C136238340 @default.
• W2760587614 hasConceptScore W2760587614C142724271 @default.
• W2760587614 hasConceptScore W2760587614C143065580 @default.
• W2760587614 hasConceptScore W2760587614C185592680 @default.
• W2760587614 hasConceptScore W2760587614C190062978 @default.
• W2760587614 hasConceptScore W2760587614C19843653 @default.
• W2760587614 hasConceptScore W2760587614C202751555 @default.
• W2760587614 hasConceptScore W2760587614C2777576037 @default.

• next