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- W2760643300 abstract "Many microbes exploit host cellular lipid droplets during the host-microbe interaction, but this phenomenon has not been extensively studied for fungal pathogens. In this study, we analyzed the role of lipid droplets during the interaction of Cryptococcus neoformans with macrophages in the presence and the absence of exogenous lipids, in particular, oleate. The addition of oleic acid increased the frequency of lipid droplets in both C. neoformans and macrophages. C. neoformans responded to oleic acid supplementation by faster growth inside and outside macrophages. Fungal cells were able to harvest lipids from macrophage lipid droplets. Supplementation of C. neoformans and macrophages with oleic acid significantly increased the rate of nonlytic exocytosis while having no effect on lytic exocytosis. The process for lipid modulation of nonlytic exocytosis was associated with actin changes in macrophages. In summary, C. neoformans harvests lipids from macrophages, and the C. neoformans-macrophage interaction is modulated by exogenous lipids, providing a new tool for studying nonlytic exocytosis." @default.
- W2760643300 created "2017-10-06" @default.
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- W2760643300 date "2017-12-01" @default.
- W2760643300 modified "2023-09-28" @default.
- W2760643300 title "Lipids Affect the Cryptococcus neoformans-Macrophage Interaction and Promote Nonlytic Exocytosis" @default.
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- W2760643300 doi "https://doi.org/10.1128/iai.00564-17" @default.
- W2760643300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5695111" @default.
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