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- W2760664544 abstract "Gaucher disease (GD) is a lysosomal storage disease caused by a partialor total deficiency of the enzyme β-glucosidase-acid, resulting inan accumulation of glucocerebroside in the lysosomes. The estimatedprevalence of symptomatic disease is 1:100000, however, in theAshkenazi Jewish population is as high as 1:450. There are more than 35mutations of the enzyme, four of them (N370S, L444P, 84insG, and IVS2)account for 90-95% of mutations in Ashkenazi Jews. This epidemiologicalfeature raised the objective to learn the migration of the Jewishpopulation in Latin America, to guide the investigation of patientswith possibilities to have GD. After the destruction of Jerusalem, wasa Jewish presence in the Iberian Peninsula for over 2500 years, andmigrated to different Latin American countries. Given the expansionthrough miscegenation is not difficult to conclude that the currentAmerican population could have a significant genetic load of Jewishorigin, so the prevalence and incidence of diseases associated withthis ethnic group should be high. Search is recommended in patientswith GD, especially in areas with lower prevalence of American natives." @default.
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- W2760664544 date "2011-06-27" @default.
- W2760664544 modified "2023-09-27" @default.
- W2760664544 title "Jewish Migration in Central America and the Caribbean: EpidemiologicalProjection of Gaucher Disease" @default.
- W2760664544 hasPublicationYear "2011" @default.
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