FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2760731207> ?p ?o ?g. }

• W2760731207 endingPage "921" @default.
• W2760731207 startingPage "909" @default.
• W2760731207 abstract "Fusarium graminearum is a causal agent of wheat scab disease and a producer of deoxynivalenol (DON) mycotoxins. Treatment with exogenous cyclic adenosine monophosphate (cAMP) increases its DON production. In this study, to better understand the role of the cAMP-protein kinase A (PKA) pathway in F. graminearum, we functionally characterized the PKR gene encoding the regulatory subunit of PKA. Mutants deleted of PKR were viable, but showed severe defects in growth, conidiation and plant infection. The pkr mutant produced compact colonies with shorter aerial hyphae with an increased number of nuclei in hyphal compartments. Mutant conidia were morphologically abnormal and appeared to undergo rapid autophagy-related cell death. The pkr mutant showed blocked perithecium development, but increased DON production. It had a disease index of less than unity and failed to spread to neighbouring spikelets. The mutant was unstable and spontaneous suppressors with a faster growth rate were often produced on older cultures. A total of 67 suppressor strains that grew faster than the original mutant were isolated. Three showed a similar growth rate and colony morphology to the wild-type, but were still defective in conidiation. Sequencing analysis with 18 candidate PKA-related genes in three representative suppressor strains identified mutations only in the CPK1 catalytic subunit gene. Further characterization showed that 10 of the other 64 suppressor strains also had mutations in CPK1. Overall, these results showed that PKR is important for the regulation of hyphal growth, reproduction, pathogenesis and DON production, and mutations in CPK1 are partially suppressive to the deletion of PKR in F. graminearum." @default.
• W2760731207 created "2017-10-06" @default.
• W2760731207 creator A5009036115 @default.
• W2760731207 creator A5009988205 @default.
• W2760731207 creator A5014954540 @default.
• W2760731207 creator A5026260090 @default.
• W2760731207 creator A5040372217 @default.
• W2760731207 creator A5079644014 @default.
• W2760731207 creator A5082827226 @default.
• W2760731207 creator A5089595904 @default.
• W2760731207 date "2017-09-20" @default.
• W2760731207 modified "2023-10-16" @default.
• W2760731207 title "The<i>PKR</i>regulatory subunit of protein kinase A (PKA) is involved in the regulation of growth, sexual and asexual development, and pathogenesis in<i>Fusarium graminearum</i>" @default.
• W2760731207 cites W1482597124 @default.
• W2760731207 cites W1490585482 @default.
• W2760731207 cites W1569134089 @default.
• W2760731207 cites W1894630692 @default.
• W2760731207 cites W1943202470 @default.
• W2760731207 cites W1966227354 @default.
• W2760731207 cites W1977090337 @default.
• W2760731207 cites W1991737559 @default.
• W2760731207 cites W1995398216 @default.
• W2760731207 cites W1996427463 @default.
• W2760731207 cites W1996571989 @default.
• W2760731207 cites W1997962605 @default.
• W2760731207 cites W2000395580 @default.
• W2760731207 cites W2016077253 @default.
• W2760731207 cites W2019738535 @default.
• W2760731207 cites W2022233825 @default.
• W2760731207 cites W2025209341 @default.
• W2760731207 cites W2042736358 @default.
• W2760731207 cites W2046411678 @default.
• W2760731207 cites W2046736343 @default.
• W2760731207 cites W2049922525 @default.
• W2760731207 cites W2067699530 @default.
• W2760731207 cites W2073372865 @default.
• W2760731207 cites W2075473569 @default.
• W2760731207 cites W2086088421 @default.
• W2760731207 cites W2087417955 @default.
• W2760731207 cites W2107277218 @default.
• W2760731207 cites W2113353075 @default.
• W2760731207 cites W2124335694 @default.
• W2760731207 cites W2124603595 @default.
• W2760731207 cites W2124621065 @default.
• W2760731207 cites W2133460832 @default.
• W2760731207 cites W2134450842 @default.
• W2760731207 cites W2138277176 @default.
• W2760731207 cites W2138751696 @default.
• W2760731207 cites W2140248780 @default.
• W2760731207 cites W2140602911 @default.
• W2760731207 cites W2140816330 @default.
• W2760731207 cites W2145999952 @default.
• W2760731207 cites W2146112868 @default.
• W2760731207 cites W2146232492 @default.
• W2760731207 cites W2148450534 @default.
• W2760731207 cites W2148718061 @default.
• W2760731207 cites W2149824831 @default.
• W2760731207 cites W2152187233 @default.
• W2760731207 cites W2152701278 @default.
• W2760731207 cites W2153213086 @default.
• W2760731207 cites W2156682932 @default.
• W2760731207 cites W2157209798 @default.
• W2760731207 cites W2166193187 @default.
• W2760731207 cites W2167737387 @default.
• W2760731207 cites W2167933269 @default.
• W2760731207 cites W2192080449 @default.
• W2760731207 cites W2345848320 @default.
• W2760731207 cites W2404513826 @default.
• W2760731207 cites W2412666212 @default.
• W2760731207 cites W2539695309 @default.
• W2760731207 cites W2544352050 @default.
• W2760731207 cites W2565379853 @default.
• W2760731207 cites W2788134167 @default.
• W2760731207 cites W54333096 @default.
• W2760731207 cites W950242780 @default.
• W2760731207 doi "https://doi.org/10.1111/mpp.12576" @default.
• W2760731207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6638095" @default.
• W2760731207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28665481" @default.
• W2760731207 hasPublicationYear "2017" @default.
• W2760731207 type Work @default.
• W2760731207 sameAs 2760731207 @default.
• W2760731207 citedByCount "18" @default.
• W2760731207 countsByYear W27607312072019 @default.
• W2760731207 countsByYear W27607312072020 @default.
• W2760731207 countsByYear W27607312072021 @default.
• W2760731207 countsByYear W27607312072022 @default.
• W2760731207 countsByYear W27607312072023 @default.
• W2760731207 crossrefType "journal-article" @default.
• W2760731207 hasAuthorship W2760731207A5009036115 @default.
• W2760731207 hasAuthorship W2760731207A5009988205 @default.
• W2760731207 hasAuthorship W2760731207A5014954540 @default.
• W2760731207 hasAuthorship W2760731207A5026260090 @default.
• W2760731207 hasAuthorship W2760731207A5040372217 @default.
• W2760731207 hasAuthorship W2760731207A5079644014 @default.
• W2760731207 hasAuthorship W2760731207A5082827226 @default.
• W2760731207 hasAuthorship W2760731207A5089595904 @default.
• W2760731207 hasBestOaLocation W27607312071 @default.
• W2760731207 hasConcept C104292427 @default.

• next