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• W2760751964 abstract "Abstract The use of noninvasive human substrates to interrogate pathophysiological conditions has become essential in the post‐ Human Genome Project era. Due to its high turnover rate, and its long term capability to incorporate exogenous and endogenous substances from the circulation, hair testing is emerging as a key player in monitoring long term drug compliance, chronic alcohol abuse, forensic toxicology, and biomarker discovery, among other things. Novel high‐throughput ‘omics based approaches like proteomics have been underutilized globally in comprehending human hair morphology and its evolving use as a diagnostic testing substrate in the era of precision medicine. There is paucity of scientific evidence that evaluates the difference in drug incorporation into hair based on lipid content, and very few studies have addressed hair growth rates, hair forms, and the biological consequences of hair grooming or bleaching. It is apparent that protein‐based identification using the human hair proteome would play a major role in understanding these parameters akin to DNA single nucleotide polymorphism profiling, up to single amino acid polymorphism resolution. Hence, this work seeks to identify and discuss the progress made thus far in the field of molecular hair testing using proteomic approaches, and identify ways in which proteomics would improve the field of hair research, considering that the human hair is mostly composed of proteins. Gaps in hair proteomics research are identified and the potential of hair proteomics in establishing a historic medical repository of normal and disease‐specific proteome is also discussed." @default.
• W2760751964 created "2017-10-06" @default.
• W2760751964 creator A5006160750 @default.
• W2760751964 creator A5008167825 @default.
• W2760751964 creator A5053058181 @default.
• W2760751964 creator A5059451989 @default.
• W2760751964 creator A5073114705 @default.
• W2760751964 creator A5074618036 @default.
• W2760751964 date "2017-10-23" @default.
• W2760751964 modified "2023-09-25" @default.
• W2760751964 title "Emerging Diagnostic and Therapeutic Potentials of Human Hair Proteomics" @default.
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