FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2760783085> ?p ?o ?g. }

• W2760783085 endingPage "322" @default.
• W2760783085 startingPage "315" @default.
• W2760783085 abstract "Multiple myeloma (MM) is characterized by progressive immune dysregulation, loss of myeloma-specific immunity, and an immunosuppressive milieu that fosters disease growth and immune escape. Accordingly, cancer vaccines that reverse tumor-associated immune suppression represent a promising therapeutic avenue of investigation. We examined the potential of an allogeneic cellular vaccine to generate immune responses against MM tumor cells. The DCOne vaccine is comprised of a human myeloid leukemia cell line differentiated into a fully functional dendritic cell, expressing a range of tumor-associated antigens that are also known targets in MM. We found that the myeloma-specific antigens expressed by the DCOne vaccine can traffic via extracellular vesicles to surrounding antigen-presenting cells, thus stimulating autologous T-cell responses. Indeed, coculture of peripheral blood mononuclear cells from patients with MM with the DCOne vaccine resulted in the expansion of activated CD8+ T cells expressing interferon-γ and perforin, with no significant change in the percentage of CD4+ T cells producing interleukin-10. Further, coculture of patient’s tumor cells with peripheral blood mononuclear cells and DCOne induced cytotoxic T-lymphocyte-mediated killing of autologous MM cells. These findings demonstrate that the allogeneic DCOne vaccine can induce T-cell activation and myeloma-specific immunity via cross presentation of antigens by native antigen-presenting cells." @default.
• W2760783085 created "2017-10-06" @default.
• W2760783085 creator A5016770040 @default.
• W2760783085 creator A5020529918 @default.
• W2760783085 creator A5022637226 @default.
• W2760783085 creator A5031452560 @default.
• W2760783085 creator A5037637724 @default.
• W2760783085 creator A5052641327 @default.
• W2760783085 creator A5054346063 @default.
• W2760783085 creator A5055553389 @default.
• W2760783085 creator A5058899283 @default.
• W2760783085 creator A5067882452 @default.
• W2760783085 creator A5071858483 @default.
• W2760783085 creator A5075337376 @default.
• W2760783085 creator A5079461625 @default.
• W2760783085 creator A5080982554 @default.
• W2760783085 creator A5091120493 @default.
• W2760783085 creator A5091439544 @default.
• W2760783085 date "2017-11-01" @default.
• W2760783085 modified "2023-09-27" @default.
• W2760783085 title "DCOne as an Allogeneic Cell-based Vaccine for Multiple Myeloma" @default.
• W2760783085 cites W1902692042 @default.
• W2760783085 cites W1970041557 @default.
• W2760783085 cites W1984768954 @default.
• W2760783085 cites W1992571529 @default.
• W2760783085 cites W2001501486 @default.
• W2760783085 cites W2011458181 @default.
• W2760783085 cites W2012345849 @default.
• W2760783085 cites W2014434555 @default.
• W2760783085 cites W2023003954 @default.
• W2760783085 cites W2038363115 @default.
• W2760783085 cites W2038710845 @default.
• W2760783085 cites W2056399811 @default.
• W2760783085 cites W2056628849 @default.
• W2760783085 cites W2057083023 @default.
• W2760783085 cites W2057965689 @default.
• W2760783085 cites W2071327437 @default.
• W2760783085 cites W2080418767 @default.
• W2760783085 cites W2085918734 @default.
• W2760783085 cites W2092572183 @default.
• W2760783085 cites W2115619738 @default.
• W2760783085 cites W2129333754 @default.
• W2760783085 cites W2143425592 @default.
• W2760783085 cites W2144728882 @default.
• W2760783085 cites W2153840858 @default.
• W2760783085 cites W2163766076 @default.
• W2760783085 cites W2182681254 @default.
• W2760783085 cites W2564288279 @default.
• W2760783085 cites W4254905735 @default.
• W2760783085 cites W4293247451 @default.
• W2760783085 doi "https://doi.org/10.1097/cji.0000000000000185" @default.
• W2760783085 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28961609" @default.
• W2760783085 hasPublicationYear "2017" @default.
• W2760783085 type Work @default.
• W2760783085 sameAs 2760783085 @default.
• W2760783085 citedByCount "12" @default.
• W2760783085 countsByYear W27607830852018 @default.
• W2760783085 countsByYear W27607830852019 @default.
• W2760783085 countsByYear W27607830852020 @default.
• W2760783085 countsByYear W27607830852021 @default.
• W2760783085 countsByYear W27607830852022 @default.
• W2760783085 crossrefType "journal-article" @default.
• W2760783085 hasAuthorship W2760783085A5016770040 @default.
• W2760783085 hasAuthorship W2760783085A5020529918 @default.
• W2760783085 hasAuthorship W2760783085A5022637226 @default.
• W2760783085 hasAuthorship W2760783085A5031452560 @default.
• W2760783085 hasAuthorship W2760783085A5037637724 @default.
• W2760783085 hasAuthorship W2760783085A5052641327 @default.
• W2760783085 hasAuthorship W2760783085A5054346063 @default.
• W2760783085 hasAuthorship W2760783085A5055553389 @default.
• W2760783085 hasAuthorship W2760783085A5058899283 @default.
• W2760783085 hasAuthorship W2760783085A5067882452 @default.
• W2760783085 hasAuthorship W2760783085A5071858483 @default.
• W2760783085 hasAuthorship W2760783085A5075337376 @default.
• W2760783085 hasAuthorship W2760783085A5079461625 @default.
• W2760783085 hasAuthorship W2760783085A5080982554 @default.
• W2760783085 hasAuthorship W2760783085A5091120493 @default.
• W2760783085 hasAuthorship W2760783085A5091439544 @default.
• W2760783085 hasConcept C147483822 @default.
• W2760783085 hasConcept C154317977 @default.
• W2760783085 hasConcept C167672396 @default.
• W2760783085 hasConcept C202751555 @default.
• W2760783085 hasConcept C203014093 @default.
• W2760783085 hasConcept C2776090121 @default.
• W2760783085 hasConcept C502942594 @default.
• W2760783085 hasConcept C55493867 @default.
• W2760783085 hasConcept C71924100 @default.
• W2760783085 hasConcept C86803240 @default.
• W2760783085 hasConcept C8891405 @default.
• W2760783085 hasConceptScore W2760783085C147483822 @default.
• W2760783085 hasConceptScore W2760783085C154317977 @default.
• W2760783085 hasConceptScore W2760783085C167672396 @default.
• W2760783085 hasConceptScore W2760783085C202751555 @default.
• W2760783085 hasConceptScore W2760783085C203014093 @default.
• W2760783085 hasConceptScore W2760783085C2776090121 @default.
• W2760783085 hasConceptScore W2760783085C502942594 @default.
• W2760783085 hasConceptScore W2760783085C55493867 @default.
• W2760783085 hasConceptScore W2760783085C71924100 @default.

• next