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• W2760784611 abstract "The present study aimed to examine whether the enzyme activity of aldehyde dehydrogenase (ALDH) was regulated by Nodal and histamine in the human alveolar adenocarcinoma A549 cell line. The regulated enzyme activity of ALDH was analyzed by flow cytometry in the A549 cell line. ALDH1 and Nodal expression was investigated by immunohistochemistry in28 cases of lung mixed adenocarcinoma. The enzyme activity of ALDH was upregulated by histamine and agonists of histamine H1 receptor (H1R) and histamine H2 receptor (H2R). ALDH activity was also downregulated by recombinant human Nodal and antagonists of H1R and H2R in the A549 cell line. In addition, expression of Nodal and ALDH1 were inversely correlated in lung mixed adenocarcinoma. ALDH enzyme activity was regulated by Nodal and histamine in lung adenocarcinoma." @default.
• W2760784611 created "2017-10-06" @default.
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• W2760784611 date "2017-09-25" @default.
• W2760784611 modified "2023-10-16" @default.
• W2760784611 title "ALDH enzyme activity is regulated by Nodal and histamine in the A549 cell line" @default.
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• W2760784611 doi "https://doi.org/10.3892/ol.2017.7057" @default.
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