Matches in SemOpenAlex for { <https://semopenalex.org/work/W2760846987> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2760846987 endingPage "1051" @default.
- W2760846987 startingPage "1046" @default.
- W2760846987 abstract "To assess the time in remission after discontinuing biologic therapy in patients with juvenile idiopathic arthritis (JIA).We enrolled 135 patients followed in 3 tertiary-care centers. The primary outcome was to assess, once remission was achieved, the time in remission up to the first flare after discontinuing treatment. Mann-Whitney U test, Wilcoxon's signed rank test for paired samples, chi-square tests, and Fisher's exact test were used to compare data. Pearson's and Spearman's correlation tests were used to determine correlation coefficients for different variables. To identify predictors of outcome, Cox regression model and Kaplan-Meier curves were constructed, each one at the mean of entered covariates.The majority of enrolled patients flared after stopping treatment with biologics (102 of 135, 75.6%) after a median followup time in remission off therapy of 6 months (range 3-109 months). A higher probability of maintaining remission after discontinuing treatment was present in systemic-onset disease compared to the rest of the JIA patients (Mantel-Cox χ2 = 8.31, P < 0.004). In analysis limited to children with JIA with polyarticular and oligoarticular disease, patients who received biologics >2 years after achieving remission had a higher probability of maintaining such remission off therapy (mean ± SD 18.64 ± 3.3 months versus 11.51 ± 2.7 months [P < 0.009]; Mantel-Cox χ2 = 9.06, P < 0.002). No other clinical variable was significantly associated with a long-lasting remission.Children with oligoarticular and polyarticular JIA who stop treatment before 2 years from remission have a higher chance of relapsing after biologic withdrawal." @default.
- W2760846987 created "2017-10-20" @default.
- W2760846987 creator A5005891890 @default.
- W2760846987 creator A5014401271 @default.
- W2760846987 creator A5017151279 @default.
- W2760846987 creator A5019760254 @default.
- W2760846987 creator A5039616289 @default.
- W2760846987 creator A5056105834 @default.
- W2760846987 creator A5063656963 @default.
- W2760846987 creator A5076611763 @default.
- W2760846987 date "2018-04-24" @default.
- W2760846987 modified "2023-10-16" @default.
- W2760846987 title "Flares After Withdrawal of Biologic Therapies in Juvenile Idiopathic Arthritis: Clinical and Laboratory Correlates of Remission Duration" @default.
- W2760846987 cites W1507110078 @default.
- W2760846987 cites W1978466826 @default.
- W2760846987 cites W2069863414 @default.
- W2760846987 cites W2099611638 @default.
- W2760846987 cites W2108546319 @default.
- W2760846987 cites W2114155762 @default.
- W2760846987 cites W2118217628 @default.
- W2760846987 cites W2125430925 @default.
- W2760846987 cites W2134389576 @default.
- W2760846987 cites W2137415116 @default.
- W2760846987 cites W2147961647 @default.
- W2760846987 cites W2154552358 @default.
- W2760846987 cites W2254729675 @default.
- W2760846987 cites W2468316178 @default.
- W2760846987 doi "https://doi.org/10.1002/acr.23435" @default.
- W2760846987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28973842" @default.
- W2760846987 hasPublicationYear "2018" @default.
- W2760846987 type Work @default.
- W2760846987 sameAs 2760846987 @default.
- W2760846987 citedByCount "26" @default.
- W2760846987 countsByYear W27608469872018 @default.
- W2760846987 countsByYear W27608469872019 @default.
- W2760846987 countsByYear W27608469872020 @default.
- W2760846987 countsByYear W27608469872021 @default.
- W2760846987 countsByYear W27608469872022 @default.
- W2760846987 countsByYear W27608469872023 @default.
- W2760846987 crossrefType "journal-article" @default.
- W2760846987 hasAuthorship W2760846987A5005891890 @default.
- W2760846987 hasAuthorship W2760846987A5014401271 @default.
- W2760846987 hasAuthorship W2760846987A5017151279 @default.
- W2760846987 hasAuthorship W2760846987A5019760254 @default.
- W2760846987 hasAuthorship W2760846987A5039616289 @default.
- W2760846987 hasAuthorship W2760846987A5056105834 @default.
- W2760846987 hasAuthorship W2760846987A5063656963 @default.
- W2760846987 hasAuthorship W2760846987A5076611763 @default.
- W2760846987 hasBestOaLocation W27608469871 @default.
- W2760846987 hasConcept C10515644 @default.
- W2760846987 hasConcept C126322002 @default.
- W2760846987 hasConcept C12868164 @default.
- W2760846987 hasConcept C141071460 @default.
- W2760846987 hasConcept C191093355 @default.
- W2760846987 hasConcept C206041023 @default.
- W2760846987 hasConcept C2777077863 @default.
- W2760846987 hasConcept C50382708 @default.
- W2760846987 hasConcept C66339696 @default.
- W2760846987 hasConcept C71924100 @default.
- W2760846987 hasConceptScore W2760846987C10515644 @default.
- W2760846987 hasConceptScore W2760846987C126322002 @default.
- W2760846987 hasConceptScore W2760846987C12868164 @default.
- W2760846987 hasConceptScore W2760846987C141071460 @default.
- W2760846987 hasConceptScore W2760846987C191093355 @default.
- W2760846987 hasConceptScore W2760846987C206041023 @default.
- W2760846987 hasConceptScore W2760846987C2777077863 @default.
- W2760846987 hasConceptScore W2760846987C50382708 @default.
- W2760846987 hasConceptScore W2760846987C66339696 @default.
- W2760846987 hasConceptScore W2760846987C71924100 @default.
- W2760846987 hasIssue "7" @default.
- W2760846987 hasLocation W27608469871 @default.
- W2760846987 hasLocation W27608469872 @default.
- W2760846987 hasLocation W27608469873 @default.
- W2760846987 hasLocation W27608469874 @default.
- W2760846987 hasOpenAccess W2760846987 @default.
- W2760846987 hasPrimaryLocation W27608469871 @default.
- W2760846987 hasRelatedWork W2037838744 @default.
- W2760846987 hasRelatedWork W2124303036 @default.
- W2760846987 hasRelatedWork W2570759941 @default.
- W2760846987 hasRelatedWork W2773181971 @default.
- W2760846987 hasRelatedWork W2995152902 @default.
- W2760846987 hasRelatedWork W3094018066 @default.
- W2760846987 hasRelatedWork W3097316003 @default.
- W2760846987 hasRelatedWork W4200339219 @default.
- W2760846987 hasRelatedWork W4211065811 @default.
- W2760846987 hasRelatedWork W4281388460 @default.
- W2760846987 hasVolume "70" @default.
- W2760846987 isParatext "false" @default.
- W2760846987 isRetracted "false" @default.
- W2760846987 magId "2760846987" @default.
- W2760846987 workType "article" @default.