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• W2760856520 abstract "Little is known about the phylogeography of norovirus (NoV) in China. In norovirus, a clear understanding for the characteristics of tree topology, migration patterns and its demographic dynamics in viral circulation are needed to identify its prevalence trends, which can help us better prepare for its epidemics as well as develop useful control strategies. The aim of this study was to explore the genetic diversity, temporal distribution, demographic dynamics and migration patterns of NoV that circulated in China.Our analysis showed that two major genogroups, GI and GII, were identified in China, in which GII.3, GII.4 and GII.17 accounted for the majority with a total proportion around 70%. Our demography inference suggested that during the long-term migration process, NoV evolved into multiple lineages and then experienced a selective sweep, which reduced its genetic diversity. The phylogeography results suggested that the norovirus may have originated form the South China (Hong Kong and Guangdong), followed by multicenter direction outbreaks across the country.From these analyses, we indicate that domestic poultry trade and frequent communications of people from different regions have all contributed to the spread of the NoV in China. Together with recent advances in phylogeographic inference, our researches also provide powerful illustrations of how coalescent-based methods can extract adequate information in molecular epidemiology." @default.
• W2760856520 created "2017-10-20" @default.
• W2760856520 creator A5019704518 @default.
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• W2760856520 date "2017-10-01" @default.
• W2760856520 modified "2023-10-16" @default.
• W2760856520 title "Genomic diversity and phylogeography of norovirus in China" @default.
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• W2760856520 doi "https://doi.org/10.1186/s12920-017-0287-9" @default.
• W2760856520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5629611" @default.
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• W2760856520 hasPublicationYear "2017" @default.
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