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- W2760857323 abstract "Consensus regarding management for patent ductus arteriosus (PDA) in preterm infants is lacking and practices vary internationally. To compare PDA treatments in very preterm infants from seven national neonatal networks worldwide. Infants born at 24–28 weeks GA during 2007–10 with birth weight (BW) <1500 g and no major congenital anomalies were retrieved from the International Network for Evaluating Outcomes in Neonates (iNeo) database. PDA treatments of pharmacologic-only, ligation-only, or both pharmacologic and ligation were compared between each country and all others, using standardized ratios (SRs) and 95% confidence intervals (CI) with adjustment for case-mix factors. SR compared the observed and expected number of infants with each PDA treatment. For each country, the expected number was determined as the sum of the predicted probabilities from a multivariable logistic model derived using data from all other countries, and adjusted for linear and quadratic GA and BW Z-score, multiple birth, sex, antenatal steroid, cesarean section, and interactions GA*BW Z-score, BW Z-score*multiple birth. Marked variations in PDA treatment rates (either pharmacologic or ligation) were detected between countries ranging from 14% in the United Kingdom Neonatal Collaborative (UKNC) to 50% of neonates in Japan who received active treatments.[figure 1]. The rates of any ligation (with or without pharmacological treatment) varied from 3.2% in UKNC to 12% in Canada. PDA treatment rates varied significantly between countries. This may relate to differences in case ascertainment, diagnostic criteria, timing of evaluation, care provision practices, availability of surgical services, or unmeasured population characteristics. Future study is required to characterize differences in selection/indication of PDA treatment approaches and their effects on infants' outcomes." @default.
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- W2760857323 date "2015-06-01" @default.
- W2760857323 modified "2023-10-16" @default.
- W2760857323 title "97: Variations in Patent Ductus Arteriosus Treatment of Very Preterm Neonates from 7 Countries: The iNeo Experience" @default.
- W2760857323 doi "https://doi.org/10.1093/pch/20.5.e69a" @default.
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