Matches in SemOpenAlex for { <https://semopenalex.org/work/W2760857591> ?p ?o ?g. }
- W2760857591 endingPage "1553" @default.
- W2760857591 startingPage "1545" @default.
- W2760857591 abstract "Purpose. This study aims to investigate the synergistic antimicrobial activity of four phytoalexins in combination with fluoroquinolones against Ureaplasma spp., a genus of cell wall-free bacteria that are intrinsically resistant to many available antibiotics, making treatment inherently difficult. Methodology. A total of 22 958 urogenital tract specimens were assessed for Ureaplasma spp. identification and antimicrobial susceptibility. From these, 31 epidemiologically unrelated strains were randomly selected for antimicrobial susceptibility testing to determine the minimum inhibitory concentration (MIC) of four fluoroquinolones and the corresponding quinolone resistance-determining regions (QRDRs). Synergistic effects between fluoroquinolones and four phytoalexins (reserpine, piperine, carvacrol and biochanin A) were evaluated by fractional inhibitory concentration indices (FICIs). Results. Analysis of the QRDRs suggested a vital role for the mutation of Ser-83→Leu in ParC in fluoroquinolone-resistant strains, and the occurrence of mutations in QRDRs showed significant associations with the breakpoint of levofloxacin. Moreover, diverse synergistic effects of the four phytoalexins with ofloxacin or ciprofloxacin were observed and biochanin A was able to enhance the antimicrobial activity of fluoroquinolones significantly. Conclusion. This is the first report of the antimicrobial activity of biochanin A in combination with fluoroquinolones against a pathogenic mycoplasma, and opens up the possibility of using components of biochanin A as a promising therapeutic option for treating antibiotic-resistant Ureaplasma spp. infections." @default.
- W2760857591 created "2017-10-20" @default.
- W2760857591 creator A5001461844 @default.
- W2760857591 creator A5006260205 @default.
- W2760857591 creator A5014708668 @default.
- W2760857591 creator A5051097212 @default.
- W2760857591 creator A5063204371 @default.
- W2760857591 creator A5064652908 @default.
- W2760857591 creator A5071672663 @default.
- W2760857591 creator A5073154855 @default.
- W2760857591 date "2017-11-01" @default.
- W2760857591 modified "2023-10-16" @default.
- W2760857591 title "Biochanin A partially restores the activity of ofloxacin and ciprofloxacin against topoisomerase IV mutation-associated fluoroquinolone-resistant Ureaplasma species" @default.
- W2760857591 cites W1627863859 @default.
- W2760857591 cites W1968364461 @default.
- W2760857591 cites W1971464939 @default.
- W2760857591 cites W1972479453 @default.
- W2760857591 cites W1998855247 @default.
- W2760857591 cites W2009119563 @default.
- W2760857591 cites W2016562927 @default.
- W2760857591 cites W2024794751 @default.
- W2760857591 cites W2025484663 @default.
- W2760857591 cites W2029219450 @default.
- W2760857591 cites W2046548856 @default.
- W2760857591 cites W2048272951 @default.
- W2760857591 cites W2059397715 @default.
- W2760857591 cites W2071127263 @default.
- W2760857591 cites W2073322102 @default.
- W2760857591 cites W2074173582 @default.
- W2760857591 cites W2087256810 @default.
- W2760857591 cites W2098536746 @default.
- W2760857591 cites W2103841681 @default.
- W2760857591 cites W2103847234 @default.
- W2760857591 cites W2108913174 @default.
- W2760857591 cites W2110025084 @default.
- W2760857591 cites W2121319673 @default.
- W2760857591 cites W2138686831 @default.
- W2760857591 cites W2143337825 @default.
- W2760857591 cites W2156449112 @default.
- W2760857591 cites W2167607362 @default.
- W2760857591 cites W2210544292 @default.
- W2760857591 cites W2238532518 @default.
- W2760857591 cites W2462759753 @default.
- W2760857591 cites W2538266348 @default.
- W2760857591 cites W2547337573 @default.
- W2760857591 cites W2550562657 @default.
- W2760857591 doi "https://doi.org/10.1099/jmm.0.000598" @default.
- W2760857591 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28984242" @default.
- W2760857591 hasPublicationYear "2017" @default.
- W2760857591 type Work @default.
- W2760857591 sameAs 2760857591 @default.
- W2760857591 citedByCount "12" @default.
- W2760857591 countsByYear W27608575912018 @default.
- W2760857591 countsByYear W27608575912019 @default.
- W2760857591 countsByYear W27608575912020 @default.
- W2760857591 countsByYear W27608575912021 @default.
- W2760857591 countsByYear W27608575912022 @default.
- W2760857591 crossrefType "journal-article" @default.
- W2760857591 hasAuthorship W2760857591A5001461844 @default.
- W2760857591 hasAuthorship W2760857591A5006260205 @default.
- W2760857591 hasAuthorship W2760857591A5014708668 @default.
- W2760857591 hasAuthorship W2760857591A5051097212 @default.
- W2760857591 hasAuthorship W2760857591A5063204371 @default.
- W2760857591 hasAuthorship W2760857591A5064652908 @default.
- W2760857591 hasAuthorship W2760857591A5071672663 @default.
- W2760857591 hasAuthorship W2760857591A5073154855 @default.
- W2760857591 hasBestOaLocation W27608575911 @default.
- W2760857591 hasConcept C104317684 @default.
- W2760857591 hasConcept C134018914 @default.
- W2760857591 hasConcept C167125095 @default.
- W2760857591 hasConcept C176947019 @default.
- W2760857591 hasConcept C2777112418 @default.
- W2760857591 hasConcept C2778049240 @default.
- W2760857591 hasConcept C2778298627 @default.
- W2760857591 hasConcept C2778512257 @default.
- W2760857591 hasConcept C2778821405 @default.
- W2760857591 hasConcept C2778838687 @default.
- W2760857591 hasConcept C2778923102 @default.
- W2760857591 hasConcept C2779922871 @default.
- W2760857591 hasConcept C2780926990 @default.
- W2760857591 hasConcept C2780955279 @default.
- W2760857591 hasConcept C2909217659 @default.
- W2760857591 hasConcept C4937899 @default.
- W2760857591 hasConcept C501593827 @default.
- W2760857591 hasConcept C547475151 @default.
- W2760857591 hasConcept C55493867 @default.
- W2760857591 hasConcept C86803240 @default.
- W2760857591 hasConcept C89423630 @default.
- W2760857591 hasConcept C98274493 @default.
- W2760857591 hasConceptScore W2760857591C104317684 @default.
- W2760857591 hasConceptScore W2760857591C134018914 @default.
- W2760857591 hasConceptScore W2760857591C167125095 @default.
- W2760857591 hasConceptScore W2760857591C176947019 @default.
- W2760857591 hasConceptScore W2760857591C2777112418 @default.
- W2760857591 hasConceptScore W2760857591C2778049240 @default.
- W2760857591 hasConceptScore W2760857591C2778298627 @default.
- W2760857591 hasConceptScore W2760857591C2778512257 @default.
- W2760857591 hasConceptScore W2760857591C2778821405 @default.