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• W2760871452 endingPage "624" @default.
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• W2760871452 abstract "Hippocampal neurogenesis is a lifelong process whereby new neurons are produced and integrate into the host circuitry within the hippocampus. It is regulated by a multitude of extrinsic and intrinsic regulators and is believed to contribute to certain hippocampal-dependent cognitive tasks. Hippocampal neurogenesis and associated cognition have been demonstrated to be impaired after increases in the levels of proinflammatory cytokine IL-1β in the hippocampus, such as that which occurs in various neurodegenerative and psychiatric disorders. IL-1β also suppresses the expression of TLX (orphan nuclear receptor tailless homolog), which is an orphan nuclear receptor that functions to promote neural progenitor cell (NPC) proliferation and suppress neuronal differentiation; therefore, manipulation of TLX represents a potential strategy with which to prevent the antiproliferative effects of IL-1β. In this study, we assessed the mechanism that underlies IL-1β–induced changes in TLX expression and determined the protective capacity of TLX to mitigate the effects of IL-1β on embryonic rat hippocampal neurosphere expansion. We demonstrate that IL-1β activated the NF-κB pathway in proliferating NPCs and that this activation was responsible for IL-1β–induced changes in TLX expression. In addition, we report that enhancing TLX expression prevented the IL-1β–induced suppression of neurosphere expansion. Thus, we highlight TLX as a potential protective regulator of the antiproliferative effects of IL-1β on hippocampal neurogenesis.—Ó’Leime, C. S., Kozareva, D. A., Hoban, A. E., Long-Smith, C. M., Cryan, J. F., Nolan, Y. M. TLX is an intrinsic regulator of the negative effects of IL-1β on proliferating hippocampal neural progenitor cells. FASEB J. 32, 613–624 (2018). www.fasebj.org" @default.
• W2760871452 created "2017-10-20" @default.
• W2760871452 creator A5033726496 @default.
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• W2760871452 date "2018-01-04" @default.
• W2760871452 modified "2023-09-23" @default.
• W2760871452 title "TLX is an intrinsic regulator of the negative effects of IL‐1β on proliferating hippocampal neural progenitor cells" @default.
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• W2760871452 doi "https://doi.org/10.1096/fj.201700495r" @default.
• W2760871452 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28970252" @default.
• W2760871452 hasPublicationYear "2018" @default.
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