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• W2760873051 endingPage "256" @default.
• W2760873051 startingPage "242" @default.
• W2760873051 abstract "Dutasteride is a 5alpha-reductase inhibitor in clinical use to treat endocrine conditions. The present study investigated the neuroprotective mechanisms of action of dutasteride in intact and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned mice using a low dose of MPTP not affecting motor activity modeling early stages of Parkinson's disease (PD). We hypothesized that dutasteride neuroprotection is due to altered steroids levels. Dutasteride pre-treatment prevented loss of striatal dopamine (DA) and its metabolite DOPAC. Dutasteride decreased effects of MPTP on striatal dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2) and D2 DA receptor specific binding while D1 receptor specific binding remained unchanged. Dutasteride enhanced DAT specific binding and the glycosylated form of DAT in intact mice. MPTP-lesioned mice had plasma and brain testosterone and dihydrotestosterone levels lower than control mice whereas progesterone and its metabolites (dihydroprogesterone, isopregnanolone and tetrahydroprogesterone) pathway showed increases. Dutasteride treatment by inhibiting transformation of progesterone and testosterone to its metabolites elevated plasma and brain concentrations of testosterone compared to MPTP mice and decreased DHT levels in intact mice. Plasma and brain estradiol levels were low and remained unchanged by MPTP and/or dutasteride treatment. Dutasteride treatment did not affect striatal phosphorylation of Akt and its downstream substrate GSK3β as well as phosphorylation of ERK1/2 in intact and MPTP lesioned MPTP mice. Striatal glial fibrillary acidic protein (GFAP) levels were markedly elevated in MPTP compared to control mice and dutasteride reduced GFAP levels in MPTP mice. Treatment with dutasteride post-lesion left unchanged striatal DA levels. These results suggest dutasteride as promising drug for PD neuroprotection." @default.
• W2760873051 created "2017-10-20" @default.
• W2760873051 creator A5008522126 @default.
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• W2760873051 date "2017-11-01" @default.
• W2760873051 modified "2023-09-25" @default.
• W2760873051 title "Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice" @default.
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• W2760873051 cites W1515063135 @default.
• W2760873051 cites W1520748992 @default.
• W2760873051 cites W1836969652 @default.
• W2760873051 cites W1937161249 @default.
• W2760873051 cites W1966575304 @default.
• W2760873051 cites W1972732038 @default.
• W2760873051 cites W1975941800 @default.
• W2760873051 cites W1976217131 @default.
• W2760873051 cites W1976707885 @default.
• W2760873051 cites W1976749972 @default.
• W2760873051 cites W1981874266 @default.
• W2760873051 cites W1983166842 @default.
• W2760873051 cites W1992879638 @default.
• W2760873051 cites W1999987381 @default.
• W2760873051 cites W2012947665 @default.
• W2760873051 cites W2014753160 @default.
• W2760873051 cites W2021144019 @default.
• W2760873051 cites W2023310799 @default.
• W2760873051 cites W2024017898 @default.
• W2760873051 cites W2025383063 @default.
• W2760873051 cites W2026698631 @default.
• W2760873051 cites W2030104137 @default.
• W2760873051 cites W2032844562 @default.
• W2760873051 cites W2032960995 @default.
• W2760873051 cites W2036734466 @default.
• W2760873051 cites W2040091808 @default.
• W2760873051 cites W2041720829 @default.
• W2760873051 cites W2046242737 @default.
• W2760873051 cites W2047818394 @default.
• W2760873051 cites W2050034414 @default.
• W2760873051 cites W2051639214 @default.
• W2760873051 cites W2052005906 @default.
• W2760873051 cites W2054222905 @default.
• W2760873051 cites W2055739274 @default.
• W2760873051 cites W2064360128 @default.
• W2760873051 cites W2067055217 @default.
• W2760873051 cites W2069077027 @default.
• W2760873051 cites W2072806037 @default.
• W2760873051 cites W2075476949 @default.
• W2760873051 cites W2076827137 @default.
• W2760873051 cites W2078644273 @default.
• W2760873051 cites W2079730191 @default.
• W2760873051 cites W2082026408 @default.
• W2760873051 cites W2087599568 @default.
• W2760873051 cites W2089466805 @default.
• W2760873051 cites W2092462980 @default.
• W2760873051 cites W2096473158 @default.
• W2760873051 cites W2098247882 @default.
• W2760873051 cites W2100193554 @default.
• W2760873051 cites W2101345641 @default.
• W2760873051 cites W2106841375 @default.
• W2760873051 cites W2109317302 @default.
• W2760873051 cites W2111464898 @default.
• W2760873051 cites W2114013531 @default.
• W2760873051 cites W2121928725 @default.
• W2760873051 cites W2122378943 @default.
• W2760873051 cites W2123812707 @default.
• W2760873051 cites W2125816605 @default.
• W2760873051 cites W2126365703 @default.
• W2760873051 cites W2133828007 @default.
• W2760873051 cites W2137814024 @default.
• W2760873051 cites W2153895095 @default.
• W2760873051 cites W2154943599 @default.
• W2760873051 cites W2158278592 @default.
• W2760873051 cites W2160500871 @default.
• W2760873051 cites W2190632089 @default.
• W2760873051 cites W2311228285 @default.
• W2760873051 cites W2338760546 @default.
• W2760873051 cites W2434485926 @default.
• W2760873051 cites W2513499869 @default.
• W2760873051 cites W2592469070 @default.
• W2760873051 cites W2625025106 @default.
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• W2760873051 doi "https://doi.org/10.1016/j.jsbmb.2017.09.021" @default.
• W2760873051 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28982631" @default.
• W2760873051 hasPublicationYear "2017" @default.
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