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• W2760873341 abstract "Significance Each year, Streptococcus pneumoniae infections cause millions of deaths worldwide. The capsular polysaccharide (CPS) based glycoconjugate vaccine Prevnar13 prevents serious illness caused by 13 serotypes. S. pneumoniae serotype 5 (ST-5) is included in the vaccine; however, it suffers from production problems due to modifications or degradation during isolation and conjugation. A medicinal chemistry approach helped to understand the structural features of ST-5 CPS and design a stable semisynthetic oligosaccharide-based vaccine candidate. Oligosaccharide leads for immunological evaluations in vivo were identified employing glycan microarrays. The stable monovalent ST-5 oligosaccharide glycoconjugate vaccine candidate showed a superior immune response in rabbits when compared with the ST-5 CPS present in the multivalent vaccine Prevnar13." @default.
• W2760873341 created "2017-10-20" @default.
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• W2760873341 date "2017-10-02" @default.
• W2760873341 modified "2023-10-18" @default.
• W2760873341 title "Semisynthetic glycoconjugate vaccine candidate against <i>Streptococcus pneumoniae</i> serotype 5" @default.
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• W2760873341 doi "https://doi.org/10.1073/pnas.1706875114" @default.
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