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- W2760887315 abstract "Innate defense regulator (IDR) peptide-1002 is a synthetic host defense peptide derivative with strong anti-inflammatory properties. Extending previous data, IDR-1002 suppressed in vitro inflammatory responses in RAW 264.7 murine monocyte/macrophage cells challenged with the TLR4 agonist LPS and TLR2 agonists lipoteichoic acid and zymosan. To investigate the anti-inflammatory mechanisms of IDR-1002 in vivo, the PMA-induced mouse ear inflammation model was used. Topical IDR-1002 treatment successfully dampened PMA-induced ear edema, proinflammatory cytokine production, reactive oxygen and nitrogen species release, and neutrophil recruitment in the ears of CD1 mice. Advanced RNA transcriptomic analysis on the mouse ear transcriptome revealed that IDR-1002 reduced sterile inflammation by suppressing the expression of transmembrane G protein-coupled receptors (class A/1 rhodopsin-like), including receptors for chemokines, PGs, histamine, platelet activating factor, and anaphylatoxin. IDR-1002 also dampened the IFN-γ response and repressed the IFN regulatory factor 8-regulated network that controls central inflammatory pathways. This study demonstrates that IDR-1002 exhibits strong in vitro and in vivo anti-inflammatory activities, informs the underlying anti-inflammatory mechanisms, and reveals its potential as a novel therapeutic for inflammatory diseases." @default.
- W2760887315 created "2017-10-20" @default.
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- W2760887315 date "2017-11-15" @default.
- W2760887315 modified "2023-09-23" @default.
- W2760887315 title "Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model" @default.
- W2760887315 cites W1566831845 @default.
- W2760887315 cites W1633660980 @default.
- W2760887315 cites W1680381655 @default.
- W2760887315 cites W1837256871 @default.
- W2760887315 cites W1854904866 @default.
- W2760887315 cites W1872482369 @default.
- W2760887315 cites W1889449109 @default.
- W2760887315 cites W1965208057 @default.
- W2760887315 cites W1965492236 @default.
- W2760887315 cites W1970141275 @default.
- W2760887315 cites W1970365072 @default.
- W2760887315 cites W1972931565 @default.
- W2760887315 cites W1973367660 @default.
- W2760887315 cites W1973836191 @default.
- W2760887315 cites W1987320336 @default.
- W2760887315 cites W1994719019 @default.
- W2760887315 cites W2000054651 @default.
- W2760887315 cites W2001603817 @default.
- W2760887315 cites W2004031232 @default.
- W2760887315 cites W2004662779 @default.
- W2760887315 cites W2005042248 @default.
- W2760887315 cites W2006766086 @default.
- W2760887315 cites W2011490477 @default.
- W2760887315 cites W2020466729 @default.
- W2760887315 cites W2031084334 @default.
- W2760887315 cites W2042851093 @default.
- W2760887315 cites W2044369639 @default.
- W2760887315 cites W2045510187 @default.
- W2760887315 cites W2045897279 @default.
- W2760887315 cites W2050805054 @default.
- W2760887315 cites W2052685738 @default.
- W2760887315 cites W2053889157 @default.
- W2760887315 cites W2056235003 @default.
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- W2760887315 cites W2063680739 @default.
- W2760887315 cites W2065698207 @default.
- W2760887315 cites W2072805330 @default.
- W2760887315 cites W2074438676 @default.
- W2760887315 cites W2078654484 @default.
- W2760887315 cites W2079911707 @default.
- W2760887315 cites W2080086899 @default.
- W2760887315 cites W2081673243 @default.
- W2760887315 cites W2084141237 @default.
- W2760887315 cites W2087243986 @default.
- W2760887315 cites W2089644287 @default.
- W2760887315 cites W2090184229 @default.
- W2760887315 cites W2092920884 @default.
- W2760887315 cites W2093577301 @default.
- W2760887315 cites W2108399976 @default.
- W2760887315 cites W2118742454 @default.
- W2760887315 cites W2130989367 @default.
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- W2760887315 cites W2134526812 @default.
- W2760887315 cites W2137311179 @default.
- W2760887315 cites W2140730939 @default.
- W2760887315 cites W2142004396 @default.
- W2760887315 cites W2143029206 @default.
- W2760887315 cites W2145266709 @default.
- W2760887315 cites W2147684469 @default.
- W2760887315 cites W2150107812 @default.
- W2760887315 cites W2150921017 @default.
- W2760887315 cites W2156626763 @default.
- W2760887315 cites W2156812233 @default.
- W2760887315 cites W2157535429 @default.
- W2760887315 cites W2162079605 @default.
- W2760887315 cites W2169456326 @default.
- W2760887315 cites W2179438025 @default.
- W2760887315 cites W2200658189 @default.
- W2760887315 cites W2264121087 @default.
- W2760887315 cites W2297060268 @default.
- W2760887315 cites W2337957188 @default.
- W2760887315 cites W2406717838 @default.
- W2760887315 cites W2432815617 @default.
- W2760887315 cites W2464717012 @default.
- W2760887315 cites W2471796556 @default.
- W2760887315 cites W2555913190 @default.
- W2760887315 cites W4229662491 @default.
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- W2760887315 doi "https://doi.org/10.4049/jimmunol.1700985" @default.
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- W2760887315 hasPublicationYear "2017" @default.
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