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- W2760897259 abstract "Significance During transcription, the mRNA may hybridize back with its template DNA, forming a structure called R loop. These structures have been associated with genome instability and human disease. Using budding yeast as a model organism to screen for new genes preventing R loops, we identified MLP1 and subsequently showed that the nuclear basket protein Mlp1/2 has a role in preventing R loop formation and genome instability in yeast. Our work indicates that R loops are formed in the nucleoplasm and that proximity of transcribed chromatin to the nuclear pore constrains R loop formation. Our study opens additional perspectives to understand the role of RNA in the control of genome integrity as a function of nuclear location." @default.
- W2760897259 created "2017-10-20" @default.
- W2760897259 creator A5032583709 @default.
- W2760897259 creator A5043281613 @default.
- W2760897259 creator A5059720536 @default.
- W2760897259 date "2017-09-25" @default.
- W2760897259 modified "2023-10-09" @default.
- W2760897259 title "Physical proximity of chromatin to nuclear pores prevents harmful R loop accumulation contributing to maintain genome stability" @default.
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- W2760897259 doi "https://doi.org/10.1073/pnas.1707845114" @default.
- W2760897259 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5642707" @default.
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