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• W2760952044 endingPage "e0184654" @default.
• W2760952044 startingPage "e0184654" @default.
• W2760952044 abstract "Background More than ten million Egyptians are infected with HCV. Every one of them is going to infect about three to four persons every year. Treating those patients is a matter of national security. A dramatic improvement in hepatitis C virus (HCV) infection treatment was achieved in the last five years. A new era of direct-acting antivirals is now dawning in Egypt. Objective(s) We share in this report our clinical experience in treating chronic HCV Egyptian patients with Sofosbuvir based regimens to evaluate its safety and efficacy on real life practical ground. Methods A total of 205 chronic HCV patients (195 naive and 15 experienced) were enrolled in the study. Patient were treated with Sofosbuvir+Ribavirin 24 weeks as standard of care. Two interferon eligible patients were treated with PEG-INF+ Sofosbuvir+Ribavirin for 12 weeks. The primary efficacy endpoint was the proportion of patients with sustained virologic response at 24 weeks after cessation of therapy. Results The overall response rate was 97.1%. Sustained virological response rate did not differ among treatment-naive patients and patients with previous history of IFN-based therapy. Portal hypertension, prediabetes, and lack of early virologic response were predictors of non response. No clinically significant treatment-emergent adverse effects were noted. No treatment discontinuation was encountered. Conclusion In the real-life setting, Sofosbuvir based regimens for 24 weeks has established an efficacious and well tolerated treatment in naïve and experienced patients with chronic HCV genotype 4 infection; although shorter treatment durations may be possible. However, patient follow up should extent to at least 6 months post-treatment and verifying viral load on yearly basis is warranted to track any late relapse." @default.
• W2760952044 created "2017-10-20" @default.
• W2760952044 creator A5057677072 @default.
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• W2760952044 date "2017-10-05" @default.
• W2760952044 modified "2023-10-04" @default.
• W2760952044 title "Real-life results of sofosbuvir based therapy in chronic hepatitis C -naïve and -experienced patients in Egypt" @default.
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• W2760952044 doi "https://doi.org/10.1371/journal.pone.0184654" @default.
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