FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2760953606> ?p ?o ?g. }

• W2760953606 endingPage "2096" @default.
• W2760953606 startingPage "2091" @default.
• W2760953606 abstract "Background & aims Increased iron stores significantly influence the clinical course of several chronic metabolic diseases. Recent studies have shown that iron overload decreases osteocalcin. We aimed to explore the relationship among osteocalcin, iron stores and insulin sensitivity. Methods Extensive clinical and laboratory measurements, including serum ferritin, cross-linked C-telopeptide of type I collagen (CTX) and osteocalcin (OC) concentrations, were analyzed in 250 adult consecutive Caucasian men. Insulin sensitivity was evaluated through frequently sampled intravenous glucose tolerance tests with minimal model analysis. Results Circulating serum ferritin were negatively associated with serum OC and CTX (p = 0.004 and p = 0.045 respectively). In all subjects as a whole, BMI and ferritin contributed to explain 5.2% of OC variance after controlling for age and smoking status. However, the association between OC and insulin sensitivity remained significant only in lean subjects (BMI < 25 kg/m2, r = 0.468; p = 0.006) whereas the link between serum ferritin concentration and OC and CTX were significant only in overweight/obese subjects (BMI ≥ 25 kg/m2, r = −0.229; p = 0.002 and r = −0.196; p = 0.008, respectively). Conclusions The association of circulating osteocalcin with parameters of insulin sensitivity and iron stores were dependent on obesity status. Increased iron stores could contribute to the detrimental metabolic effects of overweight and obesity on bone. Increased iron stores significantly influence the clinical course of several chronic metabolic diseases. Recent studies have shown that iron overload decreases osteocalcin. We aimed to explore the relationship among osteocalcin, iron stores and insulin sensitivity. Extensive clinical and laboratory measurements, including serum ferritin, cross-linked C-telopeptide of type I collagen (CTX) and osteocalcin (OC) concentrations, were analyzed in 250 adult consecutive Caucasian men. Insulin sensitivity was evaluated through frequently sampled intravenous glucose tolerance tests with minimal model analysis. Circulating serum ferritin were negatively associated with serum OC and CTX (p = 0.004 and p = 0.045 respectively). In all subjects as a whole, BMI and ferritin contributed to explain 5.2% of OC variance after controlling for age and smoking status. However, the association between OC and insulin sensitivity remained significant only in lean subjects (BMI < 25 kg/m2, r = 0.468; p = 0.006) whereas the link between serum ferritin concentration and OC and CTX were significant only in overweight/obese subjects (BMI ≥ 25 kg/m2, r = −0.229; p = 0.002 and r = −0.196; p = 0.008, respectively). The association of circulating osteocalcin with parameters of insulin sensitivity and iron stores were dependent on obesity status. Increased iron stores could contribute to the detrimental metabolic effects of overweight and obesity on bone." @default.
• W2760953606 created "2017-10-20" @default.
• W2760953606 creator A5000296743 @default.
• W2760953606 creator A5007880285 @default.
• W2760953606 creator A5012521832 @default.
• W2760953606 creator A5046970471 @default.
• W2760953606 creator A5079777621 @default.
• W2760953606 date "2018-12-01" @default.
• W2760953606 modified "2023-10-16" @default.
• W2760953606 title "Obesity status influences the relationship among serum osteocalcin, iron stores and insulin sensitivity" @default.
• W2760953606 cites W1518665512 @default.
• W2760953606 cites W1851314291 @default.
• W2760953606 cites W1965762787 @default.
• W2760953606 cites W1969776575 @default.
• W2760953606 cites W1970229070 @default.
• W2760953606 cites W1991103673 @default.
• W2760953606 cites W1992191878 @default.
• W2760953606 cites W1997578486 @default.
• W2760953606 cites W1998927491 @default.
• W2760953606 cites W2004728560 @default.
• W2760953606 cites W2006217979 @default.
• W2760953606 cites W2016763247 @default.
• W2760953606 cites W2029418234 @default.
• W2760953606 cites W2032468674 @default.
• W2760953606 cites W2033832906 @default.
• W2760953606 cites W2046392948 @default.
• W2760953606 cites W2047761422 @default.
• W2760953606 cites W2056780690 @default.
• W2760953606 cites W2073244163 @default.
• W2760953606 cites W2074494486 @default.
• W2760953606 cites W2083773097 @default.
• W2760953606 cites W2091780074 @default.
• W2760953606 cites W2093933701 @default.
• W2760953606 cites W2096080244 @default.
• W2760953606 cites W2101753582 @default.
• W2760953606 cites W2106991663 @default.
• W2760953606 cites W2108125049 @default.
• W2760953606 cites W2122426315 @default.
• W2760953606 cites W2122521998 @default.
• W2760953606 cites W2123306045 @default.
• W2760953606 cites W2125885887 @default.
• W2760953606 cites W2129109313 @default.
• W2760953606 cites W2131814354 @default.
• W2760953606 cites W2136540789 @default.
• W2760953606 cites W2140665851 @default.
• W2760953606 cites W2150780203 @default.
• W2760953606 cites W2153154688 @default.
• W2760953606 cites W2170135905 @default.
• W2760953606 cites W2235977640 @default.
• W2760953606 cites W2307586952 @default.
• W2760953606 cites W2319579244 @default.
• W2760953606 cites W2400298000 @default.
• W2760953606 cites W2413382674 @default.
• W2760953606 cites W2523768983 @default.
• W2760953606 cites W2527206197 @default.
• W2760953606 doi "https://doi.org/10.1016/j.clnu.2017.10.001" @default.
• W2760953606 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29050649" @default.
• W2760953606 hasPublicationYear "2018" @default.
• W2760953606 type Work @default.
• W2760953606 sameAs 2760953606 @default.
• W2760953606 citedByCount "3" @default.
• W2760953606 countsByYear W27609536062022 @default.
• W2760953606 countsByYear W27609536062023 @default.
• W2760953606 crossrefType "journal-article" @default.
• W2760953606 hasAuthorship W2760953606A5000296743 @default.
• W2760953606 hasAuthorship W2760953606A5007880285 @default.
• W2760953606 hasAuthorship W2760953606A5012521832 @default.
• W2760953606 hasAuthorship W2760953606A5046970471 @default.
• W2760953606 hasAuthorship W2760953606A5079777621 @default.
• W2760953606 hasConcept C126322002 @default.
• W2760953606 hasConcept C131075544 @default.
• W2760953606 hasConcept C134018914 @default.
• W2760953606 hasConcept C160160445 @default.
• W2760953606 hasConcept C181199279 @default.
• W2760953606 hasConcept C2777391703 @default.
• W2760953606 hasConcept C2778319317 @default.
• W2760953606 hasConcept C2779306644 @default.
• W2760953606 hasConcept C2780586474 @default.
• W2760953606 hasConcept C511355011 @default.
• W2760953606 hasConcept C55493867 @default.
• W2760953606 hasConcept C71924100 @default.
• W2760953606 hasConcept C86803240 @default.
• W2760953606 hasConceptScore W2760953606C126322002 @default.
• W2760953606 hasConceptScore W2760953606C131075544 @default.
• W2760953606 hasConceptScore W2760953606C134018914 @default.
• W2760953606 hasConceptScore W2760953606C160160445 @default.
• W2760953606 hasConceptScore W2760953606C181199279 @default.
• W2760953606 hasConceptScore W2760953606C2777391703 @default.
• W2760953606 hasConceptScore W2760953606C2778319317 @default.
• W2760953606 hasConceptScore W2760953606C2779306644 @default.
• W2760953606 hasConceptScore W2760953606C2780586474 @default.
• W2760953606 hasConceptScore W2760953606C511355011 @default.
• W2760953606 hasConceptScore W2760953606C55493867 @default.
• W2760953606 hasConceptScore W2760953606C71924100 @default.
• W2760953606 hasConceptScore W2760953606C86803240 @default.
• W2760953606 hasFunder F4320321595 @default.
• W2760953606 hasFunder F4320327636 @default.
• W2760953606 hasFunder F4320334923 @default.

• next