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• W2760956614 abstract "N-myc downstream regulated gene 2 (NDRG2) was a member of the N-myc down regulated gene family which belongs to the alpha/beta hydrolase superfamily and played important roles in cell death. To date, the expression and effects of NDRG2 in brain after intracerebral hemorrhage (ICH) are unclear. In this study, we investigated the spatial–temporal expression of NDRG2 in brain tissues in a rat model of ICH. The expression levels of NDRG2 were tested in 3 h, 6 h, 12 h, 24 h, 48 h, 72 h, and 7d after ICH by western blot analysis. The results showed that the NDRG2 levels were increased and peaked at 24 h after ICH, and then declined subsequently. Meanwhile, we also examined the NDRG2 cellular localization in brain tissues by immunofluorescence analysis with NeuN and GFAP (biomarker of neuron and astrocytes respectively). The results demonstrated that NDRG2 was mainly expressed in astrocytes, but not neurons, after ICH. Additionally, the results of double staining indicated that the rate of NDRG2- and TUNEL −positive cells was significantly higher in the brain tissues in rats after ICH. The roles of NDRG2 in ICH needed further investigation and inhibiting the expression of NDRG2 may have potential therapeutic effects in ICH." @default.
• W2760956614 created "2017-10-20" @default.
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• W2760956614 date "2018-01-01" @default.
• W2760956614 modified "2023-09-24" @default.
• W2760956614 title "Spatial–temporal expression of NDRG2 in brain tissues in a rat model of intracerebral hemorrhage: A pilot study" @default.
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• W2760956614 doi "https://doi.org/10.1016/j.neulet.2017.10.021" @default.
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