FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2760960219> ?p ?o ?g. }

• W2760960219 endingPage "12" @default.
• W2760960219 startingPage "1" @default.
• W2760960219 abstract "Objective: To accelerate the determination of optimal spray drying parameters, a “Design of Experiment” (DoE) software was applied to produce well redispersible hesperidin nanocrystals.Significance: For final solid dosage forms, aqueous liquid nanosuspensions need to be solidified, whereas spray drying is a large-scale cost-effective industrial process.Methods: A nanosuspension with 18% (w/w) of hesperidin stabilized by 1% (w/w) of poloxamer 188 was produced by wet bead milling. The sizes of original and redispersed spray-dried nanosuspensions were determined by laser diffractometry (LD) and photon correlation spectroscopy (PCS) and used as effect parameters. In addition, light microscopy was performed to judge the redispersion quality.Results: After a two-step design of MODDE 9, screening model and response surface model (RSM), the inlet temperature of spray dryer and the concentration of protectant (polyvinylpyrrolidone, PVP K25) were identified as the most important factors affecting the redispersion of nanocrystals. As predicted in the RSM modeling, when 5% (w/w) of PVP K25 was added in an 18% (w/w) of hesperidin nanosuspension, subsequently spray-dried at an inlet temperature of 100 °C, well redispersed solid nanocrystals with an average particle size of 276 nm were obtained. By the use of PVP K25, the saturation solubility of the redispersed nanocrystals in water was improved to 86.81 µg/ml, about 2.5-fold of the original nanosuspension. In addition, the dissolution velocity was accelerated.Conclusions: This was attributed to the additional effects of steric stabilization on the nanocrystals and solubilization by the PVP polymer from spray drying." @default.
• W2760960219 created "2017-10-20" @default.
• W2760960219 creator A5047129430 @default.
• W2760960219 creator A5057119676 @default.
• W2760960219 creator A5082807891 @default.
• W2760960219 date "2017-10-11" @default.
• W2760960219 modified "2023-09-26" @default.
• W2760960219 title "Solidification of hesperidin nanosuspension by spray drying optimized by design of experiment (DoE)" @default.
• W2760960219 cites W1966456843 @default.
• W2760960219 cites W1969047331 @default.
• W2760960219 cites W1970197346 @default.
• W2760960219 cites W1972646815 @default.
• W2760960219 cites W1973791844 @default.
• W2760960219 cites W1974532222 @default.
• W2760960219 cites W1980493995 @default.
• W2760960219 cites W1981985195 @default.
• W2760960219 cites W1983483344 @default.
• W2760960219 cites W1993660034 @default.
• W2760960219 cites W1994485361 @default.
• W2760960219 cites W2014879978 @default.
• W2760960219 cites W2015109242 @default.
• W2760960219 cites W2016971948 @default.
• W2760960219 cites W2021072600 @default.
• W2760960219 cites W2021099000 @default.
• W2760960219 cites W2021243298 @default.
• W2760960219 cites W2021713550 @default.
• W2760960219 cites W2028724994 @default.
• W2760960219 cites W2028991299 @default.
• W2760960219 cites W2030951340 @default.
• W2760960219 cites W2033911789 @default.
• W2760960219 cites W2038295804 @default.
• W2760960219 cites W2052337468 @default.
• W2760960219 cites W2054655500 @default.
• W2760960219 cites W2062105186 @default.
• W2760960219 cites W2062346329 @default.
• W2760960219 cites W2063288695 @default.
• W2760960219 cites W2080686927 @default.
• W2760960219 cites W2083840929 @default.
• W2760960219 cites W2105502591 @default.
• W2760960219 cites W2110604072 @default.
• W2760960219 cites W2111530512 @default.
• W2760960219 cites W2198126155 @default.
• W2760960219 cites W4256244642 @default.
• W2760960219 doi "https://doi.org/10.1080/03639045.2017.1285309" @default.
• W2760960219 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28967287" @default.
• W2760960219 hasPublicationYear "2017" @default.
• W2760960219 type Work @default.
• W2760960219 sameAs 2760960219 @default.
• W2760960219 citedByCount "16" @default.
• W2760960219 countsByYear W27609602192019 @default.
• W2760960219 countsByYear W27609602192020 @default.
• W2760960219 countsByYear W27609602192021 @default.
• W2760960219 countsByYear W27609602192022 @default.
• W2760960219 countsByYear W27609602192023 @default.
• W2760960219 crossrefType "journal-article" @default.
• W2760960219 hasAuthorship W2760960219A5047129430 @default.
• W2760960219 hasAuthorship W2760960219A5057119676 @default.
• W2760960219 hasAuthorship W2760960219A5082807891 @default.
• W2760960219 hasConcept C127413603 @default.
• W2760960219 hasConcept C142724271 @default.
• W2760960219 hasConcept C150077022 @default.
• W2760960219 hasConcept C155574463 @default.
• W2760960219 hasConcept C171250308 @default.
• W2760960219 hasConcept C175854130 @default.
• W2760960219 hasConcept C178790620 @default.
• W2760960219 hasConcept C184651966 @default.
• W2760960219 hasConcept C185592680 @default.
• W2760960219 hasConcept C187530423 @default.
• W2760960219 hasConcept C188027245 @default.
• W2760960219 hasConcept C192562407 @default.
• W2760960219 hasConcept C204787440 @default.
• W2760960219 hasConcept C2776128092 @default.
• W2760960219 hasConcept C2779587474 @default.
• W2760960219 hasConcept C2780077769 @default.
• W2760960219 hasConcept C42360764 @default.
• W2760960219 hasConcept C43617362 @default.
• W2760960219 hasConcept C71924100 @default.
• W2760960219 hasConcept C88380143 @default.
• W2760960219 hasConceptScore W2760960219C127413603 @default.
• W2760960219 hasConceptScore W2760960219C142724271 @default.
• W2760960219 hasConceptScore W2760960219C150077022 @default.
• W2760960219 hasConceptScore W2760960219C155574463 @default.
• W2760960219 hasConceptScore W2760960219C171250308 @default.
• W2760960219 hasConceptScore W2760960219C175854130 @default.
• W2760960219 hasConceptScore W2760960219C178790620 @default.
• W2760960219 hasConceptScore W2760960219C184651966 @default.
• W2760960219 hasConceptScore W2760960219C185592680 @default.
• W2760960219 hasConceptScore W2760960219C187530423 @default.
• W2760960219 hasConceptScore W2760960219C188027245 @default.
• W2760960219 hasConceptScore W2760960219C192562407 @default.
• W2760960219 hasConceptScore W2760960219C204787440 @default.
• W2760960219 hasConceptScore W2760960219C2776128092 @default.
• W2760960219 hasConceptScore W2760960219C2779587474 @default.
• W2760960219 hasConceptScore W2760960219C2780077769 @default.
• W2760960219 hasConceptScore W2760960219C42360764 @default.
• W2760960219 hasConceptScore W2760960219C43617362 @default.
• W2760960219 hasConceptScore W2760960219C71924100 @default.
• W2760960219 hasConceptScore W2760960219C88380143 @default.

• next