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- W2760990861 abstract "Ascorbate (Asc) is an essential compound both in animals and plants, mostly due to its reducing properties, thereby playing a role in scavenging reactive oxygen species (ROS) and acting as a cofactor in various enzymatic reactions. Recent Advances: Growing number of evidence shows that excessive Asc accumulation may have negative effects on cellular functions both in humans and plants; inter alia it may negatively affect signaling mechanisms, cellular redox status, and contribute to the production of ROS via the Fenton reaction.Both plants and humans tightly control cellular Asc levels, possibly via biosynthesis, transport, and degradation, to maintain them in an optimum concentration range, which, among other factors, is essential to minimize the potentially harmful effects of Asc. On the contrary, the Fenton reaction induced by a high-dose Asc treatment in humans enables a potential cancer-selective cell death pathway.The elucidation of Asc induced cancer selective cell death mechanisms may give us a tool to apply Asc in cancer therapy. On the contrary, the regulatory mechanisms controlling cellular Asc levels are also to be considered, for example, when aiming at generating crops with elevated Asc levels." @default.
- W2760990861 created "2017-10-20" @default.
- W2760990861 creator A5007532789 @default.
- W2760990861 creator A5044321971 @default.
- W2760990861 creator A5075960840 @default.
- W2760990861 date "2018-11-20" @default.
- W2760990861 modified "2023-09-27" @default.
- W2760990861 title "Concentration Does Matter: The Beneficial and Potentially Harmful Effects of Ascorbate in Humans and Plants" @default.
- W2760990861 cites W1489783301 @default.
- W2760990861 cites W1517698775 @default.
- W2760990861 cites W1550756377 @default.
- W2760990861 cites W1559139849 @default.
- W2760990861 cites W1700055465 @default.
- W2760990861 cites W1749735570 @default.
- W2760990861 cites W1835099507 @default.
- W2760990861 cites W1845691840 @default.
- W2760990861 cites W1863707373 @default.
- W2760990861 cites W1869302038 @default.
- W2760990861 cites W1971208758 @default.
- W2760990861 cites W1973212066 @default.
- W2760990861 cites W1975383278 @default.
- W2760990861 cites W1976586663 @default.
- W2760990861 cites W1977690447 @default.
- W2760990861 cites W1978191221 @default.
- W2760990861 cites W1978407431 @default.
- W2760990861 cites W1978548672 @default.
- W2760990861 cites W1978550480 @default.
- W2760990861 cites W1979164319 @default.
- W2760990861 cites W1980211368 @default.
- W2760990861 cites W1981278151 @default.
- W2760990861 cites W1981999048 @default.
- W2760990861 cites W1982997566 @default.
- W2760990861 cites W1983967264 @default.
- W2760990861 cites W1986035597 @default.
- W2760990861 cites W1986222438 @default.
- W2760990861 cites W1988244994 @default.
- W2760990861 cites W1988626276 @default.
- W2760990861 cites W1991064860 @default.
- W2760990861 cites W1991563020 @default.
- W2760990861 cites W1993372865 @default.
- W2760990861 cites W1993420568 @default.
- W2760990861 cites W1995207183 @default.
- W2760990861 cites W1996621445 @default.
- W2760990861 cites W1997067742 @default.
- W2760990861 cites W1997183854 @default.
- W2760990861 cites W1997208178 @default.
- W2760990861 cites W1999876250 @default.
- W2760990861 cites W2000937085 @default.
- W2760990861 cites W2002053171 @default.
- W2760990861 cites W2002699507 @default.
- W2760990861 cites W2003542984 @default.
- W2760990861 cites W2005372903 @default.
- W2760990861 cites W2005390265 @default.
- W2760990861 cites W2007823651 @default.
- W2760990861 cites W2008092267 @default.
- W2760990861 cites W2011422287 @default.
- W2760990861 cites W2012195444 @default.
- W2760990861 cites W2014190163 @default.
- W2760990861 cites W2014605920 @default.
- W2760990861 cites W2015251689 @default.
- W2760990861 cites W2016098250 @default.
- W2760990861 cites W2016165938 @default.
- W2760990861 cites W2017142925 @default.
- W2760990861 cites W2017989335 @default.
- W2760990861 cites W2018296945 @default.
- W2760990861 cites W2022826738 @default.
- W2760990861 cites W2023445016 @default.
- W2760990861 cites W2024722482 @default.
- W2760990861 cites W2025061897 @default.
- W2760990861 cites W2025623273 @default.
- W2760990861 cites W2026962311 @default.
- W2760990861 cites W2032533550 @default.
- W2760990861 cites W2032891182 @default.
- W2760990861 cites W2033222882 @default.
- W2760990861 cites W2035657489 @default.
- W2760990861 cites W2038561595 @default.
- W2760990861 cites W2044579739 @default.
- W2760990861 cites W2046274765 @default.
- W2760990861 cites W2047110122 @default.
- W2760990861 cites W2048069216 @default.
- W2760990861 cites W2056754352 @default.
- W2760990861 cites W2057146784 @default.
- W2760990861 cites W2058618870 @default.
- W2760990861 cites W2062107099 @default.
- W2760990861 cites W2062526133 @default.
- W2760990861 cites W2063403619 @default.
- W2760990861 cites W2064885787 @default.
- W2760990861 cites W2065815434 @default.
- W2760990861 cites W2066129630 @default.
- W2760990861 cites W2077993285 @default.
- W2760990861 cites W2078027210 @default.
- W2760990861 cites W2079624821 @default.
- W2760990861 cites W2080493162 @default.
- W2760990861 cites W2081496662 @default.
- W2760990861 cites W2083187720 @default.
- W2760990861 cites W2083923300 @default.
- W2760990861 cites W2085669177 @default.
- W2760990861 cites W2086552728 @default.