FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761017821> ?p ?o ?g. }

• W2761017821 abstract "Em setembro de 1987, em Goiânia-GO, Brasil, ocorreu um dos mais graves acidentesradiologicos envolvendo uma unidade de radioterapia com uma fonte de cesio-137. Umaarea de 2.000m2 foi contaminada e 249 pessoas foram expostas, tanto externa quantointernamente, a grandes doses de radiacao ionizante, resultando em 4 obitos, devido asindrome aguda da radiacao. O presente estudo analisou a ocorrencia de possiveismutacoes no cromossomo Y de homens expostos e seus descendentes do sexo masculinodivididos em dois grupos: A) 8 homens expostos acidentalmente e 8 meninos; B) 12homens expostos ocupacionalmente e 16 meninos; e o grupo controle com 8 homens e 8meninos nao expostos. O DNA foi isolado de linfocitos de sangue periferico e 30 loci(SRY, AMELY, ZFY, AZFa-Prox1, SY83, AZFa-Prox2, SY86, SY85, SY84, USP9Y,SY87, DBY, AZFa-Dist1, 12f2, AZFa-Dist2, UTYpe, SY106, SY124, SY127, SY134,SY135, SY143, SY1197, SY1291, SY1125, SY1054, YDAZ3, SY254, SY255, RH65618)foram analisados pela reacao em cadeia da polimerase. Todos os genomas apresentaramum vinculo genetico de pelo menos 99,99% de probabilidade acumulada de paternidade.Todos os individuos analisados amplificaram os STS; entretanto 4 pais (8,4%) e 8 filhos(21,2%) no grupo A, e 3 pais (7,1%) e 3 filhos (63,3%) no grupo B apresentarammutacoes. A taxa de mutacao total foi 0,11. A primeira geracao do grupo acidentalmenteexposto apresentou 7 mutacoes no SY86, 12 mutacoes no SY84, 1 mutacao nos loci 12f2 eSY135. A primeira geracao do grupo ocupacionalmente exposto apresentou 2 mutacoes noSRY, AMELY, AZFa-Prox1, AZFa-Prox2, SY86, SY85, SY84, USP9Y, SY87, AZFa-Dist1, UTYpe, SY106, SY124, SY127, SY134, SY135, SY143, SY1125, SY1054,YDAZ3, SY254, SY255, RH65618, e 4 mutacoes no 12f2. No grupo controle somente umfilho apresentou uma delecao no SY84. Acredita-se que eventos de recombinacao entreregioes repetitivas sejam a causa da alta frequencia de mutacoes de novo no cromossomoY. As mutacoes encontradas possivelmente foram geradas por mecanismos mutacionaisintrinsecos que podem ter sido aumentados pela radiacao ionizante do cesio-137. Aexposicao a radiacao ionizante de cesio-137 pode ser biomonitorada na descendencia dosindividuos expostos e a taxa de mutacao pode ser atribuida a exposicao a radiacao." @default.
• W2761017821 created "2017-10-20" @default.
• W2761017821 creator A5022827309 @default.
• W2761017821 date "2009-05-13" @default.
• W2761017821 modified "2023-09-23" @default.
• W2761017821 title "Ocorrência de mutações em loci ligados ao cromossomo Y na prole nascida de indivíduos expostos à radiação ionizante" @default.
• W2761017821 cites W1493851392 @default.
• W2761017821 cites W1535401771 @default.
• W2761017821 cites W1623272615 @default.
• W2761017821 cites W1805034335 @default.
• W2761017821 cites W1944771638 @default.
• W2761017821 cites W1963523920 @default.
• W2761017821 cites W1974101557 @default.
• W2761017821 cites W1978021099 @default.
• W2761017821 cites W1981262837 @default.
• W2761017821 cites W1987332588 @default.
• W2761017821 cites W1996406121 @default.
• W2761017821 cites W2006431749 @default.
• W2761017821 cites W2009065364 @default.
• W2761017821 cites W2010310827 @default.
• W2761017821 cites W2016838416 @default.
• W2761017821 cites W2017936139 @default.
• W2761017821 cites W2021998028 @default.
• W2761017821 cites W2027835215 @default.
• W2761017821 cites W2042694610 @default.
• W2761017821 cites W2046116280 @default.
• W2761017821 cites W2047803717 @default.
• W2761017821 cites W2054236386 @default.
• W2761017821 cites W2056421884 @default.
• W2761017821 cites W2062191182 @default.
• W2761017821 cites W2063209814 @default.
• W2761017821 cites W2076313106 @default.
• W2761017821 cites W2078075583 @default.
• W2761017821 cites W2078438633 @default.
• W2761017821 cites W2081293476 @default.
• W2761017821 cites W2084011437 @default.
• W2761017821 cites W2091476042 @default.
• W2761017821 cites W2093606206 @default.
• W2761017821 cites W2094305119 @default.
• W2761017821 cites W2095496890 @default.
• W2761017821 cites W2097512118 @default.
• W2761017821 cites W2099661599 @default.
• W2761017821 cites W2101488052 @default.
• W2761017821 cites W2101628938 @default.
• W2761017821 cites W2102696148 @default.
• W2761017821 cites W2106982327 @default.
• W2761017821 cites W2108967510 @default.
• W2761017821 cites W2110726887 @default.
• W2761017821 cites W2111822939 @default.
• W2761017821 cites W2114042090 @default.
• W2761017821 cites W2118155162 @default.
• W2761017821 cites W2124472297 @default.
• W2761017821 cites W2131014583 @default.
• W2761017821 cites W2131955331 @default.
• W2761017821 cites W2133482618 @default.
• W2761017821 cites W2136587688 @default.
• W2761017821 cites W2145378546 @default.
• W2761017821 cites W2149206879 @default.
• W2761017821 cites W2154263589 @default.
• W2761017821 cites W2156836754 @default.
• W2761017821 cites W2162579743 @default.
• W2761017821 cites W2163849750 @default.
• W2761017821 cites W2165447395 @default.
• W2761017821 cites W2166751872 @default.
• W2761017821 cites W2171465583 @default.
• W2761017821 cites W2171631664 @default.
• W2761017821 cites W2419107454 @default.
• W2761017821 cites W2474599999 @default.
• W2761017821 cites W2739222831 @default.
• W2761017821 cites W3162773084 @default.
• W2761017821 hasPublicationYear "2009" @default.
• W2761017821 type Work @default.
• W2761017821 sameAs 2761017821 @default.
• W2761017821 citedByCount "0" @default.
• W2761017821 crossrefType "dissertation" @default.
• W2761017821 hasAuthorship W2761017821A5022827309 @default.
• W2761017821 hasConcept C121332964 @default.
• W2761017821 hasConcept C138885662 @default.
• W2761017821 hasConcept C153911025 @default.
• W2761017821 hasConcept C15708023 @default.
• W2761017821 hasConcept C54355233 @default.
• W2761017821 hasConcept C86803240 @default.
• W2761017821 hasConceptScore W2761017821C121332964 @default.
• W2761017821 hasConceptScore W2761017821C138885662 @default.
• W2761017821 hasConceptScore W2761017821C153911025 @default.
• W2761017821 hasConceptScore W2761017821C15708023 @default.
• W2761017821 hasConceptScore W2761017821C54355233 @default.
• W2761017821 hasConceptScore W2761017821C86803240 @default.
• W2761017821 hasLocation W27610178211 @default.
• W2761017821 hasOpenAccess W2761017821 @default.
• W2761017821 hasPrimaryLocation W27610178211 @default.
• W2761017821 isParatext "false" @default.
• W2761017821 isRetracted "false" @default.
• W2761017821 magId "2761017821" @default.
• W2761017821 workType "dissertation" @default.