FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761035567> ?p ?o ?g. }

• W2761035567 endingPage "101" @default.
• W2761035567 startingPage "92" @default.
• W2761035567 abstract "Myelodysplastic syndromes (MDS) are a diverse group of bone marrow disorders and clonal hematopoietic stem cell disorders characterized by abnormal blood cells, or reduced peripheral blood cell count. Recent clinical studies on combination therapy of decitabine (DAC) and arsenic trioxide (ATO) have demonstrated synergy on MDS treatment, but the treatment can cause significant side effects to patients. In addition, both drugs have to be administered on a daily basis due to their short half-lives. In addressing key issues of reducing toxic side effects and improving pharmacokinetic profiles of the therapeutic agents, we have developed a new formulation by co-packaging DAC and ATO into alendronate-conjugated bone-targeting nanoparticles (BTNPs). Our pharmacokinetic studies revealed that intravenously administered BTNPs increased circulation time up to 3 days. Biodistribution analysis showed that the BTNP facilitated DAC and ATO accumulation in the bone, which is 6.7 and 7.9 times more than untargeted NP. Finally, MDS mouse model treated with BTNPs showed better restoration of complete blood count to normal level, and significantly longer median survival as compared to free drugs or untargeted NPs treatment. Our results support bone-targeted co-delivery of DAC and ATO for effective treatment of MDS." @default.
• W2761035567 created "2017-10-20" @default.
• W2761035567 creator A5021786322 @default.
• W2761035567 creator A5028264134 @default.
• W2761035567 creator A5062435881 @default.
• W2761035567 creator A5065898323 @default.
• W2761035567 creator A5070051249 @default.
• W2761035567 creator A5077025114 @default.
• W2761035567 creator A5086297961 @default.
• W2761035567 creator A5086981177 @default.
• W2761035567 creator A5089378951 @default.
• W2761035567 date "2017-12-01" @default.
• W2761035567 modified "2023-10-18" @default.
• W2761035567 title "Bone-targeting nanoparticle to co-deliver decitabine and arsenic trioxide for effective therapy of myelodysplastic syndrome with low systemic toxicity" @default.
• W2761035567 cites W1670953131 @default.
• W2761035567 cites W1901595265 @default.
• W2761035567 cites W1931471783 @default.
• W2761035567 cites W1965462179 @default.
• W2761035567 cites W1974079495 @default.
• W2761035567 cites W1976052439 @default.
• W2761035567 cites W1986253536 @default.
• W2761035567 cites W1988290689 @default.
• W2761035567 cites W1998359028 @default.
• W2761035567 cites W1999271093 @default.
• W2761035567 cites W2001445554 @default.
• W2761035567 cites W2001603955 @default.
• W2761035567 cites W2002684795 @default.
• W2761035567 cites W2010611789 @default.
• W2761035567 cites W2010976109 @default.
• W2761035567 cites W2011140047 @default.
• W2761035567 cites W2019839972 @default.
• W2761035567 cites W2027239458 @default.
• W2761035567 cites W2036181729 @default.
• W2761035567 cites W2040297553 @default.
• W2761035567 cites W2041648514 @default.
• W2761035567 cites W2045926255 @default.
• W2761035567 cites W2052265257 @default.
• W2761035567 cites W2062093164 @default.
• W2761035567 cites W2063285680 @default.
• W2761035567 cites W2070803838 @default.
• W2761035567 cites W2073495046 @default.
• W2761035567 cites W2075522584 @default.
• W2761035567 cites W2076212359 @default.
• W2761035567 cites W2079313855 @default.
• W2761035567 cites W2081279521 @default.
• W2761035567 cites W2089220360 @default.
• W2761035567 cites W2122465033 @default.
• W2761035567 cites W2125802502 @default.
• W2761035567 cites W2128291738 @default.
• W2761035567 cites W2129510594 @default.
• W2761035567 cites W2136905998 @default.
• W2761035567 cites W2155092136 @default.
• W2761035567 cites W2170340271 @default.
• W2761035567 cites W2170711824 @default.
• W2761035567 cites W2192516032 @default.
• W2761035567 cites W2221045471 @default.
• W2761035567 cites W2285408387 @default.
• W2761035567 cites W2410508711 @default.
• W2761035567 cites W2511917209 @default.
• W2761035567 cites W2511952118 @default.
• W2761035567 cites W339838209 @default.
• W2761035567 cites W4297726681 @default.
• W2761035567 doi "https://doi.org/10.1016/j.jconrel.2017.10.012" @default.
• W2761035567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5722672" @default.
• W2761035567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29042320" @default.
• W2761035567 hasPublicationYear "2017" @default.
• W2761035567 type Work @default.
• W2761035567 sameAs 2761035567 @default.
• W2761035567 citedByCount "21" @default.
• W2761035567 countsByYear W27610355672018 @default.
• W2761035567 countsByYear W27610355672019 @default.
• W2761035567 countsByYear W27610355672020 @default.
• W2761035567 countsByYear W27610355672021 @default.
• W2761035567 countsByYear W27610355672022 @default.
• W2761035567 countsByYear W27610355672023 @default.
• W2761035567 crossrefType "journal-article" @default.
• W2761035567 hasAuthorship W2761035567A5021786322 @default.
• W2761035567 hasAuthorship W2761035567A5028264134 @default.
• W2761035567 hasAuthorship W2761035567A5062435881 @default.
• W2761035567 hasAuthorship W2761035567A5065898323 @default.
• W2761035567 hasAuthorship W2761035567A5070051249 @default.
• W2761035567 hasAuthorship W2761035567A5077025114 @default.
• W2761035567 hasAuthorship W2761035567A5086297961 @default.
• W2761035567 hasAuthorship W2761035567A5086981177 @default.
• W2761035567 hasAuthorship W2761035567A5089378951 @default.
• W2761035567 hasBestOaLocation W27610355671 @default.
• W2761035567 hasConcept C104317684 @default.
• W2761035567 hasConcept C112705442 @default.
• W2761035567 hasConcept C126322002 @default.
• W2761035567 hasConcept C143998085 @default.
• W2761035567 hasConcept C150194340 @default.
• W2761035567 hasConcept C178790620 @default.
• W2761035567 hasConcept C185592680 @default.
• W2761035567 hasConcept C190727270 @default.
• W2761035567 hasConcept C19831878 @default.
• W2761035567 hasConcept C202751555 @default.
• W2761035567 hasConcept C2777807558 @default.
• W2761035567 hasConcept C2780007613 @default.

• next