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- W2761062942 abstract "Genome-wide association studies identified numerous risk loci associated with type 2 diabetes (T2D) and obesity. This study demonstrates the development of a highly sensitive label-free quantitative DNA-protein interaction approach to identify cis-regulatory variants within those loci and to uncover the affected mechanisms by identification of allele-specific transcription factor and cofactor binding. The findings at PPARG locus improve understanding of the complex mechanisms underlying genetic associations and support the “multiple enhancer hypothesis”." @default.
- W2761062942 created "2017-10-20" @default.
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- W2761062942 date "2016-01-01" @default.
- W2761062942 modified "2023-09-27" @default.
- W2761062942 title "Understanding the molecular mechanism underlying the effect of cis-regulatory variants on gene expression at T2D associated loci" @default.
- W2761062942 hasPublicationYear "2016" @default.
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