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- W2761123521 abstract "This review is a journey of the landmark erythroblast macrophage protein (Emp) discovered in 1994, and it walks chronologically through the progress that has been made in understanding the biological function of this protein. Historically, Emp was the first identified cell attachment molecule and is expressed in both erythroblasts and macrophages and mediates their attachments to form erythroblastic islands. The absence of Emp erythroblasts shows defects in differentiation and enucleation. Emp-deficient macrophages display immature morphology characterized by small sizes, round shapes, and the lack of cytoplasmic projections. Although the primary sequence of Emp has already been determined and its role in both erythroid and macrophage development is well established, there are major gaps in the understanding of its function at the molecular level. Recent studies had implicated its importance in actin cytoskeleton remodeling and cell migration, but the molecular mechanisms are still enigmatic. Previous studies have also demonstrated that downregulation of Emp affects the expression of mitogen-associated protein kinase 1 (MAPK1) and thymoma viral protooncogene (AKT-1) resulting in abnormal cell motility. In this review, we summarize the proposed function of Emp based on previous studies, present scenarios, and its plausible future in translational research." @default.
- W2761123521 created "2017-10-20" @default.
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- W2761123521 creator A5059395386 @default.
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- W2761123521 creator A5087702399 @default.
- W2761123521 date "2017-11-14" @default.
- W2761123521 modified "2023-09-27" @default.
- W2761123521 title "Erythroblast macrophage protein (Emp): Past, present, and future" @default.
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- W2761123521 cites W1966722028 @default.
- W2761123521 cites W1978373692 @default.
- W2761123521 cites W2005921785 @default.
- W2761123521 cites W2008760936 @default.
- W2761123521 cites W2008861994 @default.
- W2761123521 cites W2014130806 @default.
- W2761123521 cites W2017305404 @default.
- W2761123521 cites W2022811066 @default.
- W2761123521 cites W2023747882 @default.
- W2761123521 cites W2027407556 @default.
- W2761123521 cites W2029132363 @default.
- W2761123521 cites W2032624312 @default.
- W2761123521 cites W2033839578 @default.
- W2761123521 cites W2034818400 @default.
- W2761123521 cites W2037494215 @default.
- W2761123521 cites W2039800022 @default.
- W2761123521 cites W2048719634 @default.
- W2761123521 cites W2052730253 @default.
- W2761123521 cites W2055348159 @default.
- W2761123521 cites W2061866900 @default.
- W2761123521 cites W2063934211 @default.
- W2761123521 cites W2066005598 @default.
- W2761123521 cites W2066170259 @default.
- W2761123521 cites W2067432424 @default.
- W2761123521 cites W2069343409 @default.
- W2761123521 cites W2073389964 @default.
- W2761123521 cites W2074075770 @default.
- W2761123521 cites W2077172173 @default.
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- W2761123521 cites W2089450057 @default.
- W2761123521 cites W2100681150 @default.
- W2761123521 cites W2104161390 @default.
- W2761123521 cites W2107194336 @default.
- W2761123521 cites W2123436811 @default.
- W2761123521 cites W2127823197 @default.
- W2761123521 cites W2133841650 @default.
- W2761123521 cites W2144181069 @default.
- W2761123521 cites W2155135949 @default.
- W2761123521 cites W2157369974 @default.
- W2761123521 cites W2163969168 @default.
- W2761123521 cites W2169004893 @default.
- W2761123521 cites W2170831254 @default.
- W2761123521 cites W2184434686 @default.
- W2761123521 cites W2192136659 @default.
- W2761123521 cites W2214952942 @default.
- W2761123521 cites W2216067749 @default.
- W2761123521 cites W2335969897 @default.
- W2761123521 cites W2341818685 @default.
- W2761123521 cites W2344319761 @default.
- W2761123521 cites W2400423477 @default.
- W2761123521 cites W2406611252 @default.
- W2761123521 cites W2411442234 @default.
- W2761123521 cites W2432960098 @default.
- W2761123521 cites W2519901603 @default.
- W2761123521 cites W2559793827 @default.
- W2761123521 cites W2564448542 @default.
- W2761123521 cites W2576246387 @default.
- W2761123521 cites W2591205822 @default.
- W2761123521 cites W2592128630 @default.
- W2761123521 cites W2592722317 @default.
- W2761123521 cites W2598848404 @default.
- W2761123521 cites W2601374267 @default.
- W2761123521 cites W2603411656 @default.
- W2761123521 cites W2604785806 @default.
- W2761123521 cites W2605151545 @default.
- W2761123521 cites W2606149937 @default.
- W2761123521 cites W2606666785 @default.
- W2761123521 cites W2949589996 @default.
- W2761123521 cites W2964032982 @default.
- W2761123521 cites W4254726319 @default.
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- W2761123521 doi "https://doi.org/10.1111/ejh.12983" @default.
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- W2761123521 hasPublicationYear "2017" @default.
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