Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761180043> ?p ?o ?g. }
- W2761180043 endingPage "190" @default.
- W2761180043 startingPage "182" @default.
- W2761180043 abstract "As Pseudomonas aeruginosa infections are characterized by strong inflammation of infected tissues, anti-inflammatory therapies in combination with antibiotics have been considered for the treatment of associated diseases. Syk tyrosine kinase is an important regulator of inflammatory responses, and its specific inhibition was explored as a therapeutic option in several inflammatory conditions; however, this has not been studied in bacterial infections. We used a model of in vitro infection of human monocytic cell line THP-1 and lung epithelial cell line H292 with both wild-type and flagella-deficient mutant of P. aeruginosa strain K, as well as with clinical isolates from cystic fibrosis patients, to study the effect of a small molecule Syk inhibitor R406 on inflammatory responses induced by this pathogen. One-hour pretreatment of THP-1 cells with 10 μmol/L R406 resulted in a significant downregulation of the expression of the adhesion molecule ICAM-1, pro-inflammatory cytokines TNF-α and IL-1β, and phosphorylated signaling proteins ERK2, JNK, p-38, and IκBα, as well as significantly decreased TNF-α release by infected H292 cells. The results suggest that Syk is involved in the regulation of inflammatory responses to P. aeruginosa, and R406 may potentially be useful in dampening the damage caused by severe inflammation associated with this infection." @default.
- W2761180043 created "2017-10-20" @default.
- W2761180043 creator A5013362184 @default.
- W2761180043 creator A5052954968 @default.
- W2761180043 creator A5070586840 @default.
- W2761180043 date "2018-02-01" @default.
- W2761180043 modified "2023-10-14" @default.
- W2761180043 title "Syk inhibitor R406 downregulates inflammation in an in vitro model of <i>Pseudomonas aeruginosa</i> infection" @default.
- W2761180043 cites W1505086866 @default.
- W2761180043 cites W1523537564 @default.
- W2761180043 cites W1605822460 @default.
- W2761180043 cites W1605944323 @default.
- W2761180043 cites W1963526168 @default.
- W2761180043 cites W1965004275 @default.
- W2761180043 cites W1966511845 @default.
- W2761180043 cites W1969303703 @default.
- W2761180043 cites W1972593274 @default.
- W2761180043 cites W1976174817 @default.
- W2761180043 cites W1979921127 @default.
- W2761180043 cites W1982661637 @default.
- W2761180043 cites W1996338676 @default.
- W2761180043 cites W1996622616 @default.
- W2761180043 cites W2017341404 @default.
- W2761180043 cites W2020191191 @default.
- W2761180043 cites W2020724339 @default.
- W2761180043 cites W2025355874 @default.
- W2761180043 cites W2030074619 @default.
- W2761180043 cites W2033066280 @default.
- W2761180043 cites W2038969666 @default.
- W2761180043 cites W2052460623 @default.
- W2761180043 cites W2052874989 @default.
- W2761180043 cites W2055572755 @default.
- W2761180043 cites W2060812629 @default.
- W2761180043 cites W20714265 @default.
- W2761180043 cites W2073800111 @default.
- W2761180043 cites W2089783130 @default.
- W2761180043 cites W2091955762 @default.
- W2761180043 cites W2095726706 @default.
- W2761180043 cites W2096641887 @default.
- W2761180043 cites W2098535786 @default.
- W2761180043 cites W2099039895 @default.
- W2761180043 cites W2101935191 @default.
- W2761180043 cites W2109038233 @default.
- W2761180043 cites W2109950295 @default.
- W2761180043 cites W2110956941 @default.
- W2761180043 cites W2120222530 @default.
- W2761180043 cites W2127207030 @default.
- W2761180043 cites W2132822330 @default.
- W2761180043 cites W2135306743 @default.
- W2761180043 cites W2137412431 @default.
- W2761180043 cites W2141173291 @default.
- W2761180043 cites W2154851868 @default.
- W2761180043 cites W2155240782 @default.
- W2761180043 cites W2157883701 @default.
- W2761180043 cites W2165275387 @default.
- W2761180043 cites W2165767917 @default.
- W2761180043 cites W2169675452 @default.
- W2761180043 cites W2198803648 @default.
- W2761180043 cites W2238091472 @default.
- W2761180043 cites W2294284321 @default.
- W2761180043 cites W2345107151 @default.
- W2761180043 cites W2414467715 @default.
- W2761180043 cites W2744820186 @default.
- W2761180043 cites W4210640664 @default.
- W2761180043 cites W4246782132 @default.
- W2761180043 cites W4300659364 @default.
- W2761180043 doi "https://doi.org/10.1139/cjpp-2017-0307" @default.
- W2761180043 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29020462" @default.
- W2761180043 hasPublicationYear "2018" @default.
- W2761180043 type Work @default.
- W2761180043 sameAs 2761180043 @default.
- W2761180043 citedByCount "7" @default.
- W2761180043 countsByYear W27611800432018 @default.
- W2761180043 countsByYear W27611800432019 @default.
- W2761180043 countsByYear W27611800432021 @default.
- W2761180043 countsByYear W27611800432022 @default.
- W2761180043 crossrefType "journal-article" @default.
- W2761180043 hasAuthorship W2761180043A5013362184 @default.
- W2761180043 hasAuthorship W2761180043A5052954968 @default.
- W2761180043 hasAuthorship W2761180043A5070586840 @default.
- W2761180043 hasBestOaLocation W27611800432 @default.
- W2761180043 hasConcept C104317684 @default.
- W2761180043 hasConcept C127561419 @default.
- W2761180043 hasConcept C164027704 @default.
- W2761180043 hasConcept C203014093 @default.
- W2761180043 hasConcept C2776914184 @default.
- W2761180043 hasConcept C2777637488 @default.
- W2761180043 hasConcept C35174551 @default.
- W2761180043 hasConcept C42362537 @default.
- W2761180043 hasConcept C523546767 @default.
- W2761180043 hasConcept C54355233 @default.
- W2761180043 hasConcept C55493867 @default.
- W2761180043 hasConcept C62478195 @default.
- W2761180043 hasConcept C86803240 @default.
- W2761180043 hasConcept C89423630 @default.
- W2761180043 hasConcept C95444343 @default.
- W2761180043 hasConceptScore W2761180043C104317684 @default.
- W2761180043 hasConceptScore W2761180043C127561419 @default.