Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761181567> ?p ?o ?g. }
- W2761181567 endingPage "12850" @default.
- W2761181567 startingPage "12764" @default.
- W2761181567 abstract "The cell microenvironment has emerged as a key determinant of cell behavior and function in development, physiology, and pathophysiology. The extracellular matrix (ECM) within the cell microenvironment serves not only as a structural foundation for cells but also as a source of three-dimensional (3D) biochemical and biophysical cues that trigger and regulate cell behaviors. Increasing evidence suggests that the 3D character of the microenvironment is required for development of many critical cell responses observed in vivo, fueling a surge in the development of functional and biomimetic materials for engineering the 3D cell microenvironment. Progress in the design of such materials has improved control of cell behaviors in 3D and advanced the fields of tissue regeneration, in vitro tissue models, large-scale cell differentiation, immunotherapy, and gene therapy. However, the field is still in its infancy, and discoveries about the nature of cell-microenvironment interactions continue to overturn much early progress in the field. Key challenges continue to be dissecting the roles of chemistry, structure, mechanics, and electrophysiology in the cell microenvironment, and understanding and harnessing the roles of periodicity and drift in these factors. This review encapsulates where recent advances appear to leave the ever-shifting state of the art, and it highlights areas in which substantial potential and uncertainty remain." @default.
- W2761181567 created "2017-10-20" @default.
- W2761181567 creator A5001334715 @default.
- W2761181567 creator A5005228021 @default.
- W2761181567 creator A5032822422 @default.
- W2761181567 creator A5045242820 @default.
- W2761181567 creator A5055919572 @default.
- W2761181567 creator A5063160067 @default.
- W2761181567 creator A5066089549 @default.
- W2761181567 creator A5069040136 @default.
- W2761181567 creator A5072370779 @default.
- W2761181567 creator A5091520233 @default.
- W2761181567 date "2017-10-09" @default.
- W2761181567 modified "2023-10-18" @default.
- W2761181567 title "Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment" @default.
- W2761181567 cites W1007294394 @default.
- W2761181567 cites W106164556 @default.
- W2761181567 cites W1120477740 @default.
- W2761181567 cites W1161655524 @default.
- W2761181567 cites W1431314019 @default.
- W2761181567 cites W1482515349 @default.
- W2761181567 cites W1492176745 @default.
- W2761181567 cites W1492192767 @default.
- W2761181567 cites W1492861575 @default.
- W2761181567 cites W1505671001 @default.
- W2761181567 cites W1515338173 @default.
- W2761181567 cites W1519230909 @default.
- W2761181567 cites W1536563329 @default.
- W2761181567 cites W1539479631 @default.
- W2761181567 cites W1547388812 @default.
- W2761181567 cites W1548388249 @default.
- W2761181567 cites W1557029689 @default.
- W2761181567 cites W1574424832 @default.
- W2761181567 cites W1582334840 @default.
- W2761181567 cites W1586814698 @default.
- W2761181567 cites W1588589434 @default.
- W2761181567 cites W1592880857 @default.
- W2761181567 cites W160104111 @default.
- W2761181567 cites W1644281894 @default.
- W2761181567 cites W1655683759 @default.
- W2761181567 cites W1667567520 @default.
- W2761181567 cites W1698518057 @default.
- W2761181567 cites W1724038864 @default.
- W2761181567 cites W1748265176 @default.
- W2761181567 cites W1765863566 @default.
- W2761181567 cites W177050335 @default.
- W2761181567 cites W1773947028 @default.
- W2761181567 cites W1778513952 @default.
- W2761181567 cites W1783686579 @default.
- W2761181567 cites W1795050634 @default.
- W2761181567 cites W1795880986 @default.
- W2761181567 cites W1798466753 @default.
- W2761181567 cites W1800442676 @default.
- W2761181567 cites W1800455829 @default.
- W2761181567 cites W1813800555 @default.
- W2761181567 cites W1825744435 @default.
- W2761181567 cites W1835655851 @default.
- W2761181567 cites W1861988602 @default.
- W2761181567 cites W1863291440 @default.
- W2761181567 cites W1873493820 @default.
- W2761181567 cites W1876879565 @default.
- W2761181567 cites W1881894321 @default.
- W2761181567 cites W1885071502 @default.
- W2761181567 cites W1890402826 @default.
- W2761181567 cites W1907009818 @default.
- W2761181567 cites W1920157133 @default.
- W2761181567 cites W1924088822 @default.
- W2761181567 cites W1926427589 @default.
- W2761181567 cites W1933619036 @default.
- W2761181567 cites W1937519362 @default.
- W2761181567 cites W1947713323 @default.
- W2761181567 cites W1955400364 @default.
- W2761181567 cites W1956570055 @default.
- W2761181567 cites W1961347528 @default.
- W2761181567 cites W1963829435 @default.
- W2761181567 cites W1963892111 @default.
- W2761181567 cites W1964086310 @default.
- W2761181567 cites W1964193733 @default.
- W2761181567 cites W1964298890 @default.
- W2761181567 cites W1964413664 @default.
- W2761181567 cites W1964596167 @default.
- W2761181567 cites W1964681850 @default.
- W2761181567 cites W1964725627 @default.
- W2761181567 cites W1965329915 @default.
- W2761181567 cites W1965498876 @default.
- W2761181567 cites W1965580978 @default.
- W2761181567 cites W1965904253 @default.
- W2761181567 cites W1965933207 @default.
- W2761181567 cites W1966041584 @default.
- W2761181567 cites W1966090583 @default.
- W2761181567 cites W1966101847 @default.
- W2761181567 cites W1966296130 @default.
- W2761181567 cites W1966901825 @default.
- W2761181567 cites W1966915637 @default.
- W2761181567 cites W1967188390 @default.
- W2761181567 cites W1967268600 @default.
- W2761181567 cites W1967442587 @default.
- W2761181567 cites W1968251535 @default.