Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761209998> ?p ?o ?g. }
- W2761209998 endingPage "1353" @default.
- W2761209998 startingPage "1347" @default.
- W2761209998 abstract "Objectives Dysregulation of the cell cycle has been observed and implicated as an etiologic factor in a range of human malignancies, but remains relatively unstudied in neuroendocrine tumors (NETs). We evaluated expression of key proteins involved in cell cycle regulation in a large cohort of NETs. Methods We evaluated immunohistochemical expression of CDKN1B, CDKN1A, CDKN2A, CDK2, CDK4, CDK6, cyclin D1, cyclin E1, and phosphorylated retinoblastoma protein (phospho-RB1) in a cohort of 267 patients with NETs. We then explored associations between cell cycle protein expression, mutational status, histologic features, and overall survival. Results We found that high expression of CDK4, CDK6, CCND1, and phospho-RB1 was associated with higher proliferative index, as defined by MKI67. We additionally observed a trend toward shorter overall survival associated with low expression of CDKN1B. This association seemed strongest in SINETs (multivariate hazards ratio, 2.04; 95% confidence interval, 1.06–3.93; P = 0.03). We found no clear association between CDKN1B mutation and protein expression. Conclusions Our results suggest that dysregulation and activation of the CDK4/CDK6-CCND1-phospho-RB1 axis is associated with higher proliferative index in NETs. Investigation of the therapeutic potential of CDK4/CDK6 inhibitors in higher grade NETs is warranted." @default.
- W2761209998 created "2017-10-20" @default.
- W2761209998 creator A5017947396 @default.
- W2761209998 creator A5027283064 @default.
- W2761209998 creator A5028547202 @default.
- W2761209998 creator A5041300253 @default.
- W2761209998 creator A5041701431 @default.
- W2761209998 creator A5042340340 @default.
- W2761209998 creator A5044975989 @default.
- W2761209998 creator A5049314303 @default.
- W2761209998 creator A5056642819 @default.
- W2761209998 creator A5061396145 @default.
- W2761209998 creator A5063481044 @default.
- W2761209998 creator A5064077225 @default.
- W2761209998 creator A5064146636 @default.
- W2761209998 creator A5072727753 @default.
- W2761209998 creator A5076479991 @default.
- W2761209998 creator A5076818447 @default.
- W2761209998 creator A5085236177 @default.
- W2761209998 creator A5088794081 @default.
- W2761209998 creator A5090914326 @default.
- W2761209998 date "2017-11-01" @default.
- W2761209998 modified "2023-10-18" @default.
- W2761209998 title "Cell Cycle Protein Expression in Neuroendocrine Tumors" @default.
- W2761209998 cites W1531610392 @default.
- W2761209998 cites W1633466094 @default.
- W2761209998 cites W1772419959 @default.
- W2761209998 cites W1864174790 @default.
- W2761209998 cites W1926181167 @default.
- W2761209998 cites W1964761224 @default.
- W2761209998 cites W1969709966 @default.
- W2761209998 cites W1975781383 @default.
- W2761209998 cites W1980141404 @default.
- W2761209998 cites W1981562945 @default.
- W2761209998 cites W1985213644 @default.
- W2761209998 cites W1991912136 @default.
- W2761209998 cites W2009421925 @default.
- W2761209998 cites W2011924190 @default.
- W2761209998 cites W2018244552 @default.
- W2761209998 cites W2021638994 @default.
- W2761209998 cites W2036157787 @default.
- W2761209998 cites W2040074440 @default.
- W2761209998 cites W2049283940 @default.
- W2761209998 cites W2071333117 @default.
- W2761209998 cites W2073397208 @default.
- W2761209998 cites W2074023677 @default.
- W2761209998 cites W2088938912 @default.
- W2761209998 cites W2100908122 @default.
- W2761209998 cites W2103732635 @default.
- W2761209998 cites W2109398899 @default.
- W2761209998 cites W2115686439 @default.
- W2761209998 cites W2138519626 @default.
- W2761209998 cites W2138852366 @default.
- W2761209998 cites W2148933046 @default.
- W2761209998 cites W2149214723 @default.
- W2761209998 cites W2156804775 @default.
- W2761209998 cites W2158474413 @default.
- W2761209998 cites W2162812530 @default.
- W2761209998 cites W2164016448 @default.
- W2761209998 cites W2167834420 @default.
- W2761209998 cites W2181041512 @default.
- W2761209998 cites W2209368665 @default.
- W2761209998 cites W2210454089 @default.
- W2761209998 cites W2259852492 @default.
- W2761209998 cites W2285972463 @default.
- W2761209998 cites W2318725321 @default.
- W2761209998 cites W2341918704 @default.
- W2761209998 cites W2409896451 @default.
- W2761209998 cites W2411701108 @default.
- W2761209998 cites W2415430518 @default.
- W2761209998 cites W2416127402 @default.
- W2761209998 cites W2473332305 @default.
- W2761209998 cites W2539421776 @default.
- W2761209998 cites W2597872842 @default.
- W2761209998 doi "https://doi.org/10.1097/mpa.0000000000000944" @default.
- W2761209998 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5645256" @default.
- W2761209998 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28991877" @default.
- W2761209998 hasPublicationYear "2017" @default.
- W2761209998 type Work @default.
- W2761209998 sameAs 2761209998 @default.
- W2761209998 citedByCount "17" @default.
- W2761209998 countsByYear W27612099982018 @default.
- W2761209998 countsByYear W27612099982019 @default.
- W2761209998 countsByYear W27612099982020 @default.
- W2761209998 countsByYear W27612099982021 @default.
- W2761209998 countsByYear W27612099982022 @default.
- W2761209998 countsByYear W27612099982023 @default.
- W2761209998 crossrefType "journal-article" @default.
- W2761209998 hasAuthorship W2761209998A5017947396 @default.
- W2761209998 hasAuthorship W2761209998A5027283064 @default.
- W2761209998 hasAuthorship W2761209998A5028547202 @default.
- W2761209998 hasAuthorship W2761209998A5041300253 @default.
- W2761209998 hasAuthorship W2761209998A5041701431 @default.
- W2761209998 hasAuthorship W2761209998A5042340340 @default.
- W2761209998 hasAuthorship W2761209998A5044975989 @default.
- W2761209998 hasAuthorship W2761209998A5049314303 @default.
- W2761209998 hasAuthorship W2761209998A5056642819 @default.
- W2761209998 hasAuthorship W2761209998A5061396145 @default.