Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761216404> ?p ?o ?g. }
- W2761216404 abstract "Abstract Mammalian apurinic/apyrimidinic endonuclease 1 is a DNA repair enzyme involved in genome stability and expression of genes involved in oxidative stress responses, tumor progression and chemoresistance. However, the molecular mechanisms underlying the role of apurinic/apyrimidinic endonuclease 1 in these processes are still unclear. Recent findings point to a novel role of apurinic/apyrimidinic endonuclease 1 in RNA metabolism. Through the characterization of the interactomes of apurinic/apyrimidinic endonuclease 1 with RNA and other proteins, we demonstrate here a role for apurinic/apyrimidinic endonuclease 1 in pri-miRNA processing and stability via association with the DROSHA-processing complex during genotoxic stress. We also show that endonuclease activity of apurinic/apyrimidinic endonuclease 1 is required for the processing of miR-221/222 in regulating expression of the tumor suppressor PTEN. Analysis of a cohort of different cancers supports the relevance of our findings for tumor biology. We also show that apurinic/apyrimidinic endonuclease 1 participates in RNA-interactomes and protein-interactomes involved in cancer development, thus indicating an unsuspected post-transcriptional effect on cancer genes." @default.
- W2761216404 created "2017-10-20" @default.
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- W2761216404 date "2017-10-06" @default.
- W2761216404 modified "2023-10-06" @default.
- W2761216404 title "Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism" @default.
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- W2761216404 doi "https://doi.org/10.1038/s41467-017-00842-8" @default.
- W2761216404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5630600" @default.
- W2761216404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28986522" @default.