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• W2761230667 endingPage "10997" @default.
• W2761230667 startingPage "10983" @default.
• W2761230667 abstract "The limited recovery that occurs following stroke happens almost entirely in the first weeks postinjury. Moreover, the efficacy of rehabilitative training is limited beyond this narrow time frame. Sprouting of spared corticospinal tract axons in the contralesional spinal cord makes a significant contribution to sensorimotor recovery, but this structural plasticity is also limited to the first few weeks after stroke. Here, we tested the hypothesis that inducing plasticity in the spinal cord during chronic stroke could improve recovery from persistent sensorimotor impairment. We potentiated spinal plasticity during chronic stroke, weeks after the initial ischemic injury, in male Sprague-Dawley rats via intraspinal injections of chondroitinase ABC. Our data show that chondroitinase injections into the contralesional gray matter of the cervical spinal cord administered 28 d after stroke induced significant sprouting of corticospinal axons originating in the peri-infarct cortex. Chondroitinase ABC injection during chronic stroke without additional training resulted in moderate improvements of sensorimotor deficits. Importantly, this therapy dramatically potentiated the efficacy of rehabilitative training delivered during chronic stroke in a skilled forelimb reaching task. These novel data suggest that spinal therapy during chronic stroke can amplify the benefits of delayed rehabilitative training with the potential to reduce permanent disability in stroke survivors. SIGNIFICANCE STATEMENT The brain and spinal cord undergo adaptive rewiring (“plasticity”) following stroke. This plasticity allows for partial functional recovery from stroke induced sensorimotor impairments. However, the plasticity that underlies recovery occurs predominantly in the first weeks following stroke, and most stroke survivors are left with permanent disability even after rehabilitation. Using animal models, our data show that removal of plasticity-inhibiting signals in the spinal cord (via intraspinal injections of the enzyme chondroitinase ABC) augments rewiring of circuits connecting the brain to the spinal cord, even weeks after stroke. Moreover, this plasticity can be harnessed by rehabilitative training to significantly promote sensorimotor recovery. Thus, intraspinal therapy may augment rehabilitative training and improve recovery even in individuals living with chronic disability due to stroke." @default.
• W2761230667 created "2017-10-20" @default.
• W2761230667 creator A5033934135 @default.
• W2761230667 creator A5052908110 @default.
• W2761230667 creator A5074285789 @default.
• W2761230667 date "2017-10-12" @default.
• W2761230667 modified "2023-09-27" @default.
• W2761230667 title "Enhancing Spinal Plasticity Amplifies the Benefits of Rehabilitative Training and Improves Recovery from Stroke" @default.
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• W2761230667 doi "https://doi.org/10.1523/jneurosci.0770-17.2017" @default.
• W2761230667 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6596489" @default.
• W2761230667 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29025926" @default.
• W2761230667 hasPublicationYear "2017" @default.
• W2761230667 type Work @default.

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