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- W2761231592 abstract "Growing evidence has begun to elucidate the contribution of epigenetic mechanisms in the modulation and maintenance of gene expression and behavior. Histone acetylation is one such epigenetic mechanism, which has been shown to profoundly alter gene expression and behaviors. In this review, we begin with an overview of the major epigenetic mechanisms including histones acetylation. We next focus on recent evidence about the influence of environmental stimuli on various motivated behaviors through histone acetylation and highlight how histone deacetylase inhibitors can correct some of the pathologies linked to motivated behaviors including substance abuse, feeding and social attachments. Particularly, we emphasize that the effects of histone deacetylase inhibitors on motivated behaviors are time and context-dependent." @default.
- W2761231592 created "2017-10-20" @default.
- W2761231592 creator A5001016530 @default.
- W2761231592 creator A5039018479 @default.
- W2761231592 creator A5050281078 @default.
- W2761231592 creator A5064078073 @default.
- W2761231592 date "2019-10-01" @default.
- W2761231592 modified "2023-10-06" @default.
- W2761231592 title "Epigenetic regulation of motivated behaviors by histone deacetylase inhibitors" @default.
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