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• W2761367874 abstract "Abstract The neurovascular mechanisms underpinning the local regulation of cerebral blood flow (CBF) and oxygen transport remain elusive. In this study we have combined novel in vivo imaging of cortical microvascular and mural cell architecture with mathematical modelling of blood flow and oxygen transport, to provide new insights into CBF regulation that would be inaccessible in a conventional experimental context. Our study implicates vasomotion of smooth muscle actin-covered vessels, rather than pericyte-covered capillaries, as the main mechanism for modulating tissue oxygenation. We also resolve seemingly paradoxical observations in the literature around reduced blood velocity in response to arteriolar constrictions and deduce the cause to be propagation of constrictions to upstream penetrating arterioles. We provide support for pericytes acting as signalling conduits for upstream smooth muscle activation, and erythrocyte deformation as a complementary regulatory mechanism. Finally, we caution against the use of blood velocity as a proxy measurement for flow. Our combined imaging-modelling platform complements conventional experimentation allowing cerebrovascular physiology to be probed in unprecedented detail." @default.
• W2761367874 created "2017-10-20" @default.
• W2761367874 creator A5016183478 @default.
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• W2761367874 date "2017-09-28" @default.
• W2761367874 modified "2023-09-24" @default.
• W2761367874 title "Insights into cerebral haemodynamics and oxygenation utilising in vivo mural cell imaging and mathematical modelling" @default.
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• W2761367874 doi "https://doi.org/10.1101/195503" @default.
• W2761367874 hasPublicationYear "2017" @default.
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