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- W2761465251 abstract "Desensitization in human basophils was induced by suboptimal levels of antihuman IgE or antigen under normal calcium buffer conditions. Low doses of anti-IgE triggered only 0-12% histamine release during a 3-hour preincubation, yet initiated up to 100% desensitization upon rechallenge. After 24-27 h preincubation with allergen a, the cells did not regain releasability when rechallenged with either allergen a, allergen b or anti-IgE. Low dose, IgE-mediated desensitization in human basophils may lead to an irreversible and nonspecific inhibition of degranulation." @default.
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- W2761465251 date "1982-01-01" @default.
- W2761465251 modified "2023-10-06" @default.
- W2761465251 title "Subthreshold and Suboptimal Desensitization of Human Basophils" @default.
- W2761465251 doi "https://doi.org/10.1159/000233185" @default.
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