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• W2761477524 abstract "RNA uridylation is a potent and widespread posttranscriptional regulator of gene expression. RNA uridylation has been detected in a range of eukaryotes including trypanosomes, animals, plants, and fungi, but with the noticeable exception of budding yeast. Virtually all classes of eukaryotic RNAs can be uridylated and uridylation can also tag viral RNAs . The untemplated addition of a few uridines at the 3′ end of a transcript can have a decisive impact on RNA ’s fate. In rare instances, uridylation is an intrinsic step in the maturation of noncoding RNAs like for the U6 spliceosomal RNA or mitochondrial guide RNAs in trypanosomes. Uridylation can also switch specific miRNA precursors from a degradative to a processing mode. This switch depends on the number of uridines added which is regulated by the cellular context. Yet, the typical consequence of uridylation on mature noncoding RNAs or their precursors is to accelerate decay. Importantly, mRNAs are also tagged by uridylation. In fact, the advent of novel high throughput sequencing protocols has recently revealed the pervasiveness of mRNA uridylation, from plants to humans. As for noncoding RNAs , the main function to date for mRNA uridylation is to promote degradation. Yet, additional roles begin to be ascribed to U‐tailing such as the control of mRNA deadenylation, translation control and possibly storage. All these new findings illustrate that we are just beginning to appreciate the diversity of roles played by RNA uridylation and its full temporal and spatial implication in regulating gene expression. WIREs RNA 2018, 9:e1440. doi: 10.1002/wrna.1440 This article is categorized under: RNA Processing > 3′ End Processing RNA Processing > RNA Editing and Modification RNA Turnover and Surveillance > Turnover/Surveillance Mechanisms" @default.
• W2761477524 created "2017-10-20" @default.
• W2761477524 creator A5012931823 @default.
• W2761477524 creator A5047500964 @default.
• W2761477524 creator A5066849990 @default.
• W2761477524 creator A5089402623 @default.
• W2761477524 date "2017-10-05" @default.
• W2761477524 modified "2023-10-12" @default.
• W2761477524 title "<scp>RNA</scp> uridylation: a key posttranscriptional modification shaping the coding and noncoding transcriptome" @default.
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