FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2761525287> ?p ?o ?g. }

• W2761525287 endingPage "10" @default.
• W2761525287 startingPage "1" @default.
• W2761525287 abstract "Children that are born preterm are at an increased risk of developing cognitive problems and behavioural disorders, such as attention deficit hyperactivity disorder (ADHD). There is increasing interest in the role of the cerebellum in these processes and the potential involvement of GABAergic pathways in neurodevelopmental disorders. We propose that preterm birth, and the associated loss of the trophic intrauterine environment, alters the development of the cerebellum, contributing to ongoing neurobehavioral disorders.Guinea pigs were delivered preterm (GA62) or spontaneously at term (GA69), and tissues collected at corrected postnatal day (PND) 28. Neurodevelopmental and GABAergic markers myelin basic protein (MBP), neuronal nuclei (NeuN), calbindin (Purkinje cells), and GAD67 (GABA synthesis enzyme) were analysed in cerebellar lobules IX and X by immunohistochemistry. Protein expression of GAD67 and GAT1 (GABA transporter enzyme) were quantified by western blot, whilst neurosteroid-sensitive GABAA receptor subunits were measured by RT-PCR.MBP immunostaining was increased in lobule IX of preterm males, and reduced in lobule X of preterm females when compared to their term counterparts. GAD67 staining was decreased in lobule IX and X of the preterm males, but only in lobule X of the preterm females compared to term cohorts for each sex. Internal granule cell layer width of lobule X was decreased in preterm cohorts of both sexes compared to terms. There were no differences between gestational age groups for NeuN staining, GAD67 and GAT1 protein expression as measured by western blotting, or GABAA receptor subunits as measured by RT-PCR between preterm and term for either sex.The present findings suggest that components of the cerebellar GABAergic system of the ex-preterm cerebellum are disrupted. The higher expression of myelin in the preterm males may be due to a deficit in axonal pruning, whereas females have a deficit in myelination at 28 corrected days of age. Together these ongoing alterations may contribute to the neurodevelopmental and behavioural disorders observed in those born preterm." @default.
• W2761525287 created "2017-10-20" @default.
• W2761525287 creator A5008079998 @default.
• W2761525287 creator A5020495844 @default.
• W2761525287 creator A5028153177 @default.
• W2761525287 creator A5038391174 @default.
• W2761525287 creator A5038552488 @default.
• W2761525287 date "2017-10-09" @default.
• W2761525287 modified "2023-10-03" @default.
• W2761525287 title "Disruptions to the cerebellar GABAergic system in juvenile guinea pigs following preterm birth" @default.
• W2761525287 cites W1588629441 @default.
• W2761525287 cites W1589412808 @default.
• W2761525287 cites W1906182678 @default.
• W2761525287 cites W1965375794 @default.
• W2761525287 cites W1968627331 @default.
• W2761525287 cites W1969786859 @default.
• W2761525287 cites W1976887222 @default.
• W2761525287 cites W1985242817 @default.
• W2761525287 cites W1985892724 @default.
• W2761525287 cites W1991119987 @default.
• W2761525287 cites W1994532676 @default.
• W2761525287 cites W1996341174 @default.
• W2761525287 cites W2000266912 @default.
• W2761525287 cites W2001555806 @default.
• W2761525287 cites W2002418277 @default.
• W2761525287 cites W2004922568 @default.
• W2761525287 cites W2009477259 @default.
• W2761525287 cites W2015477350 @default.
• W2761525287 cites W2015811197 @default.
• W2761525287 cites W2018648849 @default.
• W2761525287 cites W2033447709 @default.
• W2761525287 cites W2034446966 @default.
• W2761525287 cites W2034813029 @default.
• W2761525287 cites W2044855063 @default.
• W2761525287 cites W2047662887 @default.
• W2761525287 cites W2047801483 @default.
• W2761525287 cites W2049096633 @default.
• W2761525287 cites W2051178577 @default.
• W2761525287 cites W2055109204 @default.
• W2761525287 cites W2061043823 @default.
• W2761525287 cites W2064363302 @default.
• W2761525287 cites W2067011924 @default.
• W2761525287 cites W2071990213 @default.
• W2761525287 cites W2072008965 @default.
• W2761525287 cites W2072370095 @default.
• W2761525287 cites W2078981560 @default.
• W2761525287 cites W2079086000 @default.
• W2761525287 cites W2084145713 @default.
• W2761525287 cites W2087399490 @default.
• W2761525287 cites W2088980803 @default.
• W2761525287 cites W2094763657 @default.
• W2761525287 cites W2100728233 @default.
• W2761525287 cites W2104366240 @default.
• W2761525287 cites W2104460069 @default.
• W2761525287 cites W2110373085 @default.
• W2761525287 cites W2115583232 @default.
• W2761525287 cites W2116897930 @default.
• W2761525287 cites W2117506912 @default.
• W2761525287 cites W2123811191 @default.
• W2761525287 cites W2125277337 @default.
• W2761525287 cites W2125442557 @default.
• W2761525287 cites W2127510146 @default.
• W2761525287 cites W2128284178 @default.
• W2761525287 cites W2132008729 @default.
• W2761525287 cites W2134776603 @default.
• W2761525287 cites W2138652400 @default.
• W2761525287 cites W2146509630 @default.
• W2761525287 cites W2148399921 @default.
• W2761525287 cites W2148586550 @default.
• W2761525287 cites W2150088940 @default.
• W2761525287 cites W2158441042 @default.
• W2761525287 cites W2158451955 @default.
• W2761525287 cites W2159750050 @default.
• W2761525287 cites W2160596115 @default.
• W2761525287 cites W2167605442 @default.
• W2761525287 cites W2170112692 @default.
• W2761525287 cites W2239920470 @default.
• W2761525287 cites W2326136915 @default.
• W2761525287 cites W2427129100 @default.
• W2761525287 cites W2566161814 @default.
• W2761525287 cites W2622882503 @default.
• W2761525287 cites W3191740793 @default.
• W2761525287 doi "https://doi.org/10.1016/j.ijdevneu.2017.10.002" @default.
• W2761525287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29024720" @default.
• W2761525287 hasPublicationYear "2017" @default.
• W2761525287 type Work @default.
• W2761525287 sameAs 2761525287 @default.
• W2761525287 citedByCount "18" @default.
• W2761525287 countsByYear W27615252872018 @default.
• W2761525287 countsByYear W27615252872019 @default.
• W2761525287 countsByYear W27615252872020 @default.
• W2761525287 countsByYear W27615252872021 @default.
• W2761525287 countsByYear W27615252872022 @default.
• W2761525287 countsByYear W27615252872023 @default.
• W2761525287 crossrefType "journal-article" @default.
• W2761525287 hasAuthorship W2761525287A5008079998 @default.
• W2761525287 hasAuthorship W2761525287A5020495844 @default.
• W2761525287 hasAuthorship W2761525287A5028153177 @default.

• next